ECTOPIC GCS IN RA · Cellular and molecular dynamics of ectopic germinal centre formation in rheumatoid arthritis
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2006-08-01 → 2008-07-31
- EU contribution
- €89,836
- Participants
- 1
- Scheme
- EIF
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Project objective
B lymphocytes are key effector cells in adaptive immune responses against foreign antigens, by producing antibodies and processing and presenting the antigen to T lymphocytes. In healthy individuals B lymphocyte differentiation and maturation takes place in the germinal centres of peripheral lymphoid organs.However, in chronic inflammatory autoimmune diseases (e.g. rheumatoid arthritis, Sjogren syndrome) ectopic germinal centres develop at the sites of inflammation, allowing an (auto)antigen dependent immune response, thus perpetuating the inflammation, and eventually breaking the tolerance mechanisms.Therefore, using both mathematical and animal models, the aim of the present proposal is to clarify the genetic, molecular and cellular mechanisms underlying abnormal B lymphocyte development and function and the formation and maintenance of ectopic germinal centres in autoimmune diseases.
Original text from CORDIS.
Participants
- FUNDAÇÃO CALOUSTE GULBENKIAN · LISBOACoordinatorPortugal
Links
Data: CORDIS, © European Union