NSTSMNP · Novel strategies for the total synthesis of bioactive macrocyclic natural products
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2006-12-01 → 2008-11-30
- EU contribution
- €159,613
- Participants
- 1
- Scheme
- EIF
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Results in brief
Final Activity Report Summary - NSTSMNP (Novel strategies for the total synthesis of bioactive macrocyclic natural products)
The synthesis of natural products has provided ample opportunities for organic chemist to exercise their creative skills. This creativity has found wider application in the fine chemicals industry, the pharmaceutical industry in particular, and resulted in the development of methodology applicable in a variety of syntheses. The objective of this research project concerned the synthesis of two resorcylate natural products with potential bio-activity, the important anabolic, estrogenic and antibacterial macrolide zearalenone and the potent antifungal agent 15G256ß (previously not synthesized), through concise and simplified biomimetic-like routes. During this project, we have developed a new strategy for the synthesis of resorcylate natural products using a biomimetic highly-selective late-stage aromatization reaction and its application to concise total syntheses of the antifungal natural products 15G256beta, 15G256iota, the mycotoxin S-(-)-zearalenone, and the related antibiotic natural resorcylates W1278A, B and C.
Data: CORDIS, © European Union
Project objective
The synthesis of natural compounds with biological activity is one of the most important areas in organic chemistry, and also for the agrochemical and pharmaceutical industry.Polyketides are the most abundant medicinal agents among natural products. Structural diversity and wide scope of bioactivities are typical of the group. This proposal is focused upon the synthesis of resorcylate bio-active natural products and the underlying synthetic methodology.The objective of this research project is the total synthesis of two resorcylate natural products with potential bio-activity, the important anabolic, estrogenic and antibacterial macrolide zearalenone and the potent antifungal agent 15G256b (previously not synthesized), through concise and simplified bio mimetic-like routes.The methodology that will be used for the development of the synthetic route will be based on lactone macrocyclisation using enyne metathesis reaction and calcium (II) catalytic transesterification as key steps, also studying the scope o f these reactions in the synthesis of polyfunctionalised targets.The development of the project will contribute positively to my career development as a scientist, offering me the key experiences to mature and enhance my career in the future as an independent researcher.It will be beneficial for the objectives of the European Research Area because it will qualify me to develop my future career inside the European Community completing my scientist training with trans-national mobility, a strategic goal for the European Policy training objectives.
Original text from CORDIS.
Participants
- IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE · LONDONCoordinatorCity levelUnited Kingdom
Links
Data: CORDIS, © European Union