NADIBA · Non-linear analysis of dynamic interactions between brain areas
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2007-02-01 → 2008-01-31
- EU contribution
- €58,478
- Participants
- 1
- Scheme
- EIF
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Results in brief
Final Activity Report Summary - NADIBA (Non-linear analysis of dynamic interactions between brain areas)
The way the brain areas communicate during different mental tasks or under specific conditions, or the way they interact with different physiological control systems is not yet clarified. The NADIBA project contributed to the understanding of communication within the brain areas by proposing some methods to reveal the cerebral interactions and brain influences by means of extracting the information from event-related potentials (ERP). The functional magnetic determination of how brain areas communicated during different mental tasks or under specific conditions, or how they interacted under different physiological control systems was not yet clarified. NADIBA contributed to the understanding of communication between brain areas by proposing methods which revealed cerebral interactions and brain influences using data from ERP, functional magnetic resonance imaging (fMRI), electroencephalogram (EEG) and cerebral blood flow (CBF). To investigate effective connectivity in the brain, the Granger causality index was applied, based on time variant and time invariant connectivity models and considering linear and non-linear models. The principal aims of the project were to: 1. elucidate how brain areas communicated in the constitution of pain, 2. clarify how brain areas interacted during orthographic and phonological tasks in an attempt to explain difficulties of dyslexic children in executing linguistic tasks, 3. reveal the connectivity network existing between primary motor cortex (M1), supplementary motor area (SMA) and pre-supplementary motor area (preSMA) during finger tapping by means of analysis of the fMRI recordings and 4. investigate interactions between heart rate, blood pressure, cerebral blood pressure and respiration, as well as their regulation by the autonomic nervous system.
Data: CORDIS, © European Union
Project objective
NABIDA will develop new methods to analyse the interactions between brain areas using functional neuroimaging data (event-related potentials [ERP] and functional magnetic resonance imaging data [fMRI]) to improve our understanding of communication within the brain. These new methodological approaches have great promise for stimulating development of diagnostic, rehabilitative and therapeutic measures for patients with brain dysfunctions, e.g. stroke.Such dysfunctions can be reflected in a change of the dynamics of coordination and organization of the interactions between brain areas. The activation of brain areas can be quantified using imaging techniques like electroencephalogram (EEG), magnetoencephalo-graphy (MEG), and fMRI. NABIDA will solve some of the analytical challenges that stand in the way of making optimal analysis and interpretation of these data.Specifically, NABIDA will develop new multivariate, time-variant, non-linear analysis methods to quantify dynamics of the interaction processes for both modalities and to find correlations between signal modalities from EEG (especially ERP) and fMRI. NABIDA will both develop these techniques and apply them to data collected under controlled experiments to evaluate their effectiveness.NABIDA merges the biomedical engineering skills of the applicant with the international excellence of the host in biomedical engineering as well as signal and image processing, taking advantage of a strong interdisciplinary and multidisciplinary cooperation of research groups that integrates mathematicians, physicists, engineers, physicians and psychologists.
Original text from CORDIS.
Participants
- FRIEDRICH SCHILLER UNIVERSITY · JENACoordinatorCity levelGermany
Links
Data: CORDIS, © European Union