SYNBIOTIC GLYCOARRAY · Glycans array fingerprints for the study of synbiotics
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- 2007-02-01 → 2007-09-30
- EU contribution
- €80,000
- Participants
- 1
- Scheme
- IRG
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Results in brief
Final Activity and Management Report Summary - SYNBIOTIC GLYCOARRAY (Glycans array fingerprints for the study of synbiotics)
The project aimed at putting together a platform for analysis of syniotics - products in which prebiotics polymers are mixed with probiotic bacteria and combined benefits are achieved. The goal of this project was to be able to look at each component separately as well as to look at combined attributes in term of chemical composition as evident using 'Carbodeep'(tm) fingerprinting. The project started with massive improvement and adaptation of the platform used for probiotics with the task to increase resolution of the platform and adaptation to the normal market use envisioned by us and by our customers. An improved platform was developed and alpha tested by potential customer. The project did not progress all the way to beta testing.
Data: CORDIS, © European Union
Project objective
A growing awareness of the relationship between diet and health has led to an increasing demand for food products that are able to enhance health, as well as provide basic nutrition. Synbiotics are functional foods that combine probiotics (living microorganisms) and their substrates - prebiotics. Synbiotics demonstrate synergistic health benefits on the consumer. Synbiotics' mode of action is poorly understood. Even so, it is suggested that synbiotics have antimicrobial, anticarcinogenic, immunomodulatory, antidiarrheal, antiallergenic, and other activities. Therefore, scientific documentation is of major importance for the credibility of the synbiotic products. Glycans play an important part in human nutrition; these include glycoconjugate molecules that are part of food ingredients and secreted glycans from microorganisms in food fermentation.The issue of glycan analysis technology is repeatedly mentioned as key to the development of safer and better food. As the new head of biochemistry in NutriCognia, I will combine the company technology with the expertise I acquired in the USA to make use of synbiotics' glycan composition as a scientific tool for the characterization and monitoring of synbiotic aspects. Our approach to glycan analysis is based on lectin glycan interactions: glycoanalysis is performed by binding the intact glycoprotein to a lectin array (CarboDeep) and identification by specifically labelled lectin probes. CarboDeep presents a unique approach, that enables efficient, precise, qualitative, and quantitative methods for the study of synbiotics.We propose to:(1) optimise CarboDeep technology for the synbiotics field;(2) develop synbiotic glyco-fingerprinting application, using the synbiotics' glycans biochip; and (3) develop a biochip with higher specificity for synbiotics' glycans.The proposed studies will provide a reliable scientific/technological tool for synbiotics analysis and afford a new insight of the synbiotics properties.
Original text from CORDIS.
Participants
- NUTRICOGNIA LTD · ASHDODCoordinatorCity levelIsrael
Links
Data: CORDIS, © European Union