JIMPYSPEC · Investigation of metabolic processes underlying brain myelination defects using magnetic resonance spectroscopy of oligodendrocyte extracts
FP6 — Marie Curie Actions (Human Resources and Mobility)
- Duration
- —
- EU contribution
- €80,000
- Participants
- 1
- Scheme
- IRG
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Project objective
Genetic factors are responsible for many degenerative diseases of the nervous system. Proteolipid protein (PLP), the most abundant myelin protein of the central nervous system (CNS), is positioned in compact myelin, and alterations in the processing of PLP are a major cause in inherited diseases of CNS myelin. For instance, the Pelizaeus Merzbacher disease is a disorder of the central nervous myelination, caused in most cases by mutations involving the PLP gene.It has been known for several years that myelin formation in the mammalian CNS is closely related to the oligodendrocyte population, and that the latter may be regulated by apoptosis. It is also known that PLP mutations resulting in demyelination lead to extended oligodendrocyte apoptosis. The proposed research aim is to investigate metabolic processes underlying myelination defects in the CNS.
Original text from CORDIS.
Participants
- UNIVERSITE LOUIS PASTEUR · STRASBOURGCoordinatorFrance
Links
Data: CORDIS, © European Union