MIXPLAN · Mixed field dosimetry and NCT treatment planning

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Project objective

Transfer of knowledge and research of the project concern mixed high-and low-LET radiation dosimetry with special attention to its application in neutron capture therapy a binary treatment modality based on nuclear reactions initiated by capture of thermal neutrons by initially non radioctive nuclei with high cross section for such a capture. At present, the reaction with boron atoms (10B) is used for so called boron neutron capture therapy (BNCT). In this case, a boron nucleus captures thermal neutron producing an alpha particle and 7Li ion.After 10B has been delivered selectively to tumour cells, it can be activated by neutrons to deliver locally lethal high-LET radiation. Tissues exposed to neutron beams are subject to a mixture of absorbed dose components. The most important components in tissue can be identified as photon dose, fast neutron dose and absorbed dose due to capture reactions notably in nitrogen and, in the case of BNCT, neutron capture also in boron.

Original text from CORDIS.

Participants

• INSTYTUT ENERGII ATOMOWEJ (INSTITUTE OF ATOMIC ENERGY)CoordinatorCity levelPoland
• STUDSVIK MEDICAL ABCity levelSweden

Links

• View on CORDIS