OPTIBIO · Optical resonances for label-free biosensing
FP7 — People (Marie Curie Actions)
- Duration
- 2008-11-17 → 2011-11-16
- EU contribution
- €45,000
- Participants
- 2
- Scheme
- MC-ERG
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Results in brief
Optical resonances for label-free biosensing
In the framework of the Marie Curie Reintegration Project Robert Horvath joined the Research Institute of Technical Physics and Materials Science (MFA) and could return work in his home country, Hungary, continuing the momentum built up by 7 years of very fruitful research in Denmark and in England. At the host institute a long term strategic plan is to build up a strong research direction in the field of bio-and chemical sensing and to conduct basic and applied research in these fields. The reintegrated researcher significantly strengthened this direction with his relevant experiences in the field of optical waveguide based biosensors and their applications. Particularly, during the project novel optical waveguide based sensors were developed for label-free sensing of biomolecules and living cells. A new sensing concept, Grating Coupled Interferometry, was introduced for high resolution and cost-effective label-free sensing. Planar optical sensors were also used to monitor the surface adhesion of proteins, nanoparticles and the surface assembly of flagellin based films. Theoretical modeling of these resonator structures were also investigated, mainly focusing on anisotropic effects in the deposited layers. Using the fellowship Robert Horvath started to create his own research group by building up a new laboratory and supervising nine BSc, MSc or PhD level students in the above-mentioned scientific topics. After the fellowship, he was granted a 5 years "Lendblet" career development grant by the Hungarian Academy of Sciences fully completing his reintegration in Hungary.
Data: CORDIS, © European Union
Project objective
In case of successful evaluation of the present application Robert Horvath plans to join to the Research Institute of Technical Physics and Materials Science (MFA) and can return work in his home country, continuing the momentum built up by 7 years of very fruitful research abroad. At the host institute a long term strategic plan is to build up a strong research direction in the field of bio- and chemical sensing and conduct basic and applied research in these fields. The applicant could strengthen this research direction with his relevant experiences in the field of optical waveguide based biosensors and their applications. Particularly, the present project aims to develop novel optical waveguide based sensors capable of supporting more detailed information about the structure of thin films or living cells with increased sensitivity in a label-free manner. This is achieved by designing and fabricating novel waveguide configurations supporting several modes and using different excitation wavelengths. Especially, novel Si and metal-oxide processing technology available at the host institute will be explored and combined with the applicants experience in soft lithography. The fabricated sensors will be applied to test and develop a novel sensor matrix based on functionalized protein assemblies for detecting small analytes and living cells. Theoretical modelling of these resonator structures and their sensing capabilities will be an important part of the research.
Original text from CORDIS.
Participants
Links
Data: CORDIS, © European Union