IMMEEDIA · Immunomodulatory Effects of Exercise in Type 1 Diabetes
FP7 — People (Marie Curie Actions)
- Duration
- 2010-07-01 → 2014-06-30
- EU contribution
- €399,600
- Participants
- 5
- Scheme
- MC-IRSES
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Results in brief
Immunomodulatory Effects of Exercise in Type 1 Diabetes
The general objective of this grant was to understand the extent to which exercise may ameliorate the progression of the autoimmune process and inflammatory pathways associated with beta cell dysfunction/destruction in type 1 diabetes (T1DM) and type 2 diabetes (T2DM). To verify whether exercise was capable of counteracting the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, our consortium envisaged a multi-approach strategy consisting of: - administration of a tailored exercise training program in different cohorts of T1DM-subjects; - in-vivo animal models challenged with exercise; - cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses; A common thread across the spectrum of diabetes is the dysregulation of immune system function, and beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. It is nowadays clear that marked immune aberrancies are linked to several metabolic disease. Exercise is a cornerstone in the prevention, cure and treatment of all-species metabolic disturbances. This exchange scheme aimed at developing research and training activities, specifically those in which physical exercise could be beneficial for the treatment of TD1M.
Data: CORDIS, © European Union
Project objective
Diabetes is a major metabolic disease with huge costs for healthcare system throughout the EU and worldwide. Type 1 Diabetes (T1DM) is a chronic condition in which pancreas produces little or no insulin, believed to result from a disorder of immunoregulation. For decades it has been known that regular aerobic exercise improves insulin sensitivity in diabetic patients, reducing insulin requirements. Traditionally, physical exercise has been promoted in type 2 diabetes, where insulin action is deficient in the context of insulin resistance and/or inappropriate insulin secretion. However, even in T1DM, in the dysregulation of immune system function, beta-cell toxicity is mediated by a complex interplay between oxidative stress and inflammation, for which exercise could be protective. Preliminary observations in fact indicate that regularly exercising T1DM-subjects have lower autoimmunity markers at an early stage of the disease. We want to ascertain the effect of moderate regular exercise as the most convenient measure to avoid the onset/worsening of T1DM. To verify whether exercise is capable of countering the T1DM-autoimmune process directed against beta-cells of the pancreatic islets, a multi-centric study will include: a) administration of a tailored exercise training program in different cohorts of T1DM-subjects; b) in-vivo animal experiments in which gain/loss-function models will be challenged with exercise; c) cell studies to analyse the exercise effects on signal transduction pathways and cytokine responses; d) metabolic profiling and metabolomic studies concerning the multicomponent analysis of biological fluids, tissue and cell extracts. Our consortium, through this multi-approach strategy, will reveal how exercise may exert a potent immunomodulatory effect, reducing the autoimmune response that in T1DM attacks and destroys the insulin producing cells.
Original text from CORDIS.
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Data: CORDIS, © European Union