RESVERATROL ROLES · Resveratrol-induced molecular markers in cancer and progenitor cells proliferation
FP7 — People (Marie Curie Actions)
- Duration
- 2011-01-01 → 2014-12-31
- EU contribution
- €100,000
- Participants
- 1
- Scheme
- MC-IRG
Lines connect the coordinator with its partners.
Results in brief
Resveratrol-induced molecular markers in cancer and progenitor cells proliferation
Organogenesis involves a balance between expansion in the number of undifferentiated progenitor cells (PC) and withdrawal of cells from this pool through differentiation. Understanding how this balance is achieved is relevant to a number of clinical problems such as progression of cancer. PCs are essential for the maintenance and regeneration of organs and tissues that exhibit high rates of cell turnover or regenerative reserve. Moreover, at the organism level, alterations in PCs homeostasis balance are clearly fundamental to physiological processes, such as organ development, and to pathological events, such as cancer. Moreover, recent studies supports the model that early event in carcinogenesis is invariably associated with molecular alteration of endogenous pancreatic PCs (PPCs) homeostasis. Here we elucidated whole transcriptome of a recently identified PPCs that are modulated by resveratrol in vitro treatment; and at this stage we are studing a novel gene regulatory network potentially amenable to new diagnostic, prognostic and therapeutic targets in pancreatic cancer.
Data: CORDIS, © European Union
Project objective
Many genes that have been shown to cause cancer were originally identified because of their role in embryonic development and in the postnatal control of cell growth and differentiation. The similarities between cancer and development are evident on many levels. Microscopically, cancerous tissues frequently appear as undifferentiated masses, with some tumor types exhibiting embryonic tissue organization. The increased mobility of cancer cells, leading to local invasion or metastasis, is reminiscent of the migratory behavior of cells during development. We aim to have deeper tumor biology knowledge through gene regulatory network (GRN) models. We consider the characterization of GRNs of tissue specific progenitor/stem cells as a paramount to our understanding of cancerogenesis in colon, lung, and pharynx (CLP) tumor cells. This research proposal underlies the hypothesis that some cancer cells are closely related to progenitor cell of respective tissue, therefore the tumor drug selection should resemble proper stem/progenitor cell differentiation signaling pathway perturbation. We believe that such tumor-customized drug treatment will be more successful, it will shed light on the comprehension of drug effect overall. Moreover it will highlight new aspects of developmental and cancer biology mechanisms. We will use spheroid in vitro model and moreover we will adopt mouse model to validate in vitro data. The predicted outcome of this research is the identification of novel gene regulatory interactions that will be investigated for their roles in carcinogenetic tissues.
Original text from CORDIS.
Participants
- ISTITUTO NAZIONALE TUMORI Fondazione Pascale · NapoliCoordinatorItaly
Links
Data: CORDIS, © European Union