ReTeBESKO · Rechargeable Telemetry-Based Electrochemical Sensors: Kidney Oxygenation and health
FP7 — People (Marie Curie Actions)
- Duration
- 2011-06-01 → 2014-05-31
- EU contribution
- €238,119
- Participants
- 1
- Scheme
- MC-IOF
Lines connect the coordinator with its partners.
Results in brief
Rechargeable Telemetry-Based Electrochemical Sensors: Kidney Oxygenation and health.
Chronic Kidney Disease (CKD) is a growing global public health problem. Low kidney tissue oxygen and CKD are associated. However investigation of kidney oxygen regulation has not been possible because of an inability to measure kidney tissue oxygen for long periods in vivo. Within this project we have developed and validated a world first technology which allows wireless measurement of kidney tissue oxygen in unrestrained rats. These validation studies have recently been published in the prestigious American Journal of Physiology (Renal). We hypothesize that this cutting edge oxygen sensor can be used to test the involvement of fundamental controllers in long-term regulation of kidney tissue oxygenation. Indeed the developed and tested oxygen telemetry technology can track changes in oxygen levels in different locations in the kidney and allows continuous measurement of oxygen for at least 3 months. This could be used to study the temporal relation between low kidney tissue oxygen and the progression of CKD, which was already demonstrated in our most recent experiments. Furthermore we believe that the fellow has used this Marie Curie fellowship very effectively and has been able to successfully transfer relevant research knowledge and skills from New Zealand to the EU in general and the Netherlands in particular. This is exemplified by; • 3 publications in peer-reviewed journals and 1 manuscript in preparation; • 9 invitations to speak at international meeting (of which 7 in Europe); • 8 poster and 1 oral presentations at international conferences; • 8 collaborations with international research laboratories; • Establishing oxygen telemetry at UMC Utrecht and Maastricht University; • Establishing renal nerve recording at UMC Utrecht; • Supervising an internship of 6 months; • Receiving 4 extra mural research grants (AMRF project, IRSES, RSNZ, BHF Fellowship) which has a total of just over €1 million; • Teaching 2 sessions ‘Advanced Integrative Physiology’ (Medsci 734; 2012); • Teaching a second semester of ‘Regulation & Integrations Physiology’ (GNK 1.7; 2012).
Data: CORDIS, © European Union
Project objective
Translational research for human health on major diseases such as cancer, cardiovascular disease, diabetes and obesity requires modalities that can monitor an ever widening spectrum of physiological signals over extended periods of time in animal models unhindered by anaesthesia or restraint. We hypothesize that a novel generation of in vivo rechargeable, telemetry-based electrochemical sensors will facilitate continuous recording of a hitherto uncharted spectrum of signals in different tissues and thereby will hugely improve testing and validation of new drugs as well as our understanding of physiology and pathophysiology.Elucidating the link between renal oxygenation and kidney health, will have major impact in the clinical practice, making it a very promising and timely subject. To allow such a breakthrough this proposal will start with the realisation of a telemetry-based solution for chronic measurement of oxygen in the kidney.This inherently multidisciplinary project will partner with the University of Auckland, a leading site in biomedical engineering, for the development and testing of novel telemetry devices. In acute experiments surgical methods and hardware will be refined and tested before progressing to experiments in conscious animals. Thereafter renal oxygen will be continuously recorded in an accepted rat model of chronic kidney disease without and with therapy to confirm disturbed oxygen homeostasis and to evaluate treatment efficacy.This fellowship will not only generate groundbreaking technology, knowledge and expertise to study kidney oxygenation, but it will also allow me to be at the forefront of a new area in physiology research. On my return to the home institute we will be able force breakthroughs within the European Research Area for mechanistic studies on hypoxia-dependent progression of kidney disease.
Original text from CORDIS.
Participants
- UNIVERSITAIR MEDISCH CENTRUM UTRECHT · UtrechtCoordinatorNetherlands
Links
Data: CORDIS, © European Union