gene therapy

R-FunSel · In vivo functional screening via CRISPR-Cas9 to systematically identify cardiomyocyte receptors as targets for the innovative therapies for myocardial infarction and heart failure

TCRabX · Structural basis for the therapeutic efficiency of optimal-affinity T cell receptors

2 partners · 2 countries

iMED · International Doctoral Programme in Molecular Mechanisms of Disease

MiniBRAIN · Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids.

MITOPOMPE · Targeting mitochondrial defects and oxidative stress in Pompe Disease: from pathogenesis to therapy

rDNAstress · Novel insights into DNA damage and stress responses in the nucleolus: Mechanisms and relevance for genomic (in)stability and cancer

Alpha-Synuclein · Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors.

StarT · European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder

16 partners · 8 countries

HELPHERGEN · THE GENETIC BASIS OF MATING BEHAVIOR: PHEROMONE COMMUNICATION IN NOCTUID MOTHS

ItohRibo · Structural study on mitochondrial ribosome assembly in human cells

transLEISHion · A targeted knockout screen for identification of Leishmania membrane transporters required for infection of macrophages

NeuroLSD · Neuro-metabolic, structural and functional hallmarks of Lysosomal Storage Diseases

TOLKEDA · Modulating brain structural plasticity versus neurodegeneration via a novel mechanism involving neurotrophins and dopamine, Tolls and Kek truncated-Trk-like receptors in Drosophila.

SHARE_WW · Spatial organization and Horizontal gene transfer of Antibiotic Resistance by ESBL in WasteWater

GSAS · Genomic Strategies Against STB disease of wheat

TOMATO EXODERMIS · Development and drought responses of tomato exodermis

Sialoglycan Array · Generation of a Cell-Based Sialoglycan Array to Decipher Biological Interactions and Functions of the Human Sialome

CXCR4THERAPY · IMPROVING HEMATOPOIETIC STEM CELL- BASED GENE THERAPY OUTCOME BY MODULATING CXCR4 EXPRESSION

INTERGLU · Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools

MeloCRISP · Implementation of CRISPR/Cas9 technology in melon to edit fruit ripening and CMV resistant genes

SUPERMIN · Correlative Super Resolution Imaging of the Collagen Mineralization Process

2 partners

StressPFCog · Mechanisms of stress-induced cognitive deficits : Role of the glucocorticoid receptor and its partners in the regulation of PFC function.

ZNEOPSIN_II · The role of novel opsins in non-visual light detection in the zebrafish brain

THAT IS HUNT · Triggering Haematological Adoptive T-cell Immunotherapy Strategies by HUnting Novel T-cell receptors