oncology

FOX-mTN · Dissecting FOXO-mediated Transcription Noise to Stall Cellular Dysfunction in Ageing

NONCO-MICROTIS · Exploiting single cell long non-coding RNA biology to target therapy-induced senescence in lung cancer

POC-TDM · Development of a point-of-care microfluidic device for Therapeutic Drug Monitoring in cancer treatment (POC-TDM)

DARTSin · The Telosome: Deciphering the architecture of the shelterin complex and its network

ADC2GBM · Development of brain-permeable masked nanobody-drug conjugates to eliminate glioma stem cells

OVADEX · Defining the role of the tumor microenvironment in treatment resistance of OVArian cancer through patient-Derived EXplants (OVADEX)

2 partners · 2 countries

ViHiHippo · Viral hijacking of the Hippo pathway - HCMV-encoded viral GPCRs US28 and UL78 differentially modulate the Hippo pathway in cancer.

RESEMBLE · Long-read sequencing to resolve the missing heritability in patients suspected of PTEN hamartoma tumour syndrome

EpiPolyPharma · Development of dual-targeting epigenetic modulators for polypharmacology-based cancer therapy

2 partners

StapPep · Stapled peptide analogues as inhibitors of the CCR4-NOT complex to regulate the mRNA degradation

METACIL · Unveiling the molecular interplay between primary cilia and metabolism in cancer

MechHelicaseActiv8on · Unravelling the mechanism of eukaryotic helicase activation

Onco-inflammation · Origin of genomic instability: Understanding the biological influence of inflammation in the initiation of pancreatic tumorigenesis

SENOXIA · Hypoxic regulation of senescent cells secretome in lung cancer and Alzheimer's disease

HAUITCC · Habitable Air: Urban Inequality in the Time of Climate Change

TopNanoBiosen · Rationally optimized, nanostructure-based biosensors for multi-biomarker cancer diagnostics

2 partners

PROTACs · Design, synthesis and biological evaluation of PROteolysis-TArgeting Chimeric (PROTAC) molecules as anticancer agents

HodgkINsights · Hodgkin Lymphoma: Insights from genomic studies of mutations in coding and non-coding regions

MIC · Multi messenger Imaging of Cancer

DIEAML · Deciphering immune evasion of Acute Myeloid Leukemia

BreaKer · Dissecting how breast cancer-associated inflammation shapes invariant natural killer T cell activity during metastatic progression

Chemical Mutagenesis · a powerful tool for the creation of a library of nanobodies

TREXSpliceosome · Investigating the structural basis of TREX function in mRNA export using cryo-electron microscopy and super-resolution fluorescence microscopy

NECESSITY · New prECision thErapieS for uveal melanoma (targeting the Gαq/GNAQ oncogenic Signaling cIrcuiTrY)

2 partners · 2 countries