oncology

Optimisation of retroviral vectors for gene transfer to human pluripotenthematopoietic cells and application to chronic granulomatous disease

Structure/function studies on the activation of the met receptorprotein-tyrosine kinase

Cell cycle control in the fission yeast schizosaccharomyces pombe

Study of new signaling pathways involving grb2/grb3-3 isoforms

The role of apc tumor suppressor gene in development and tumorigenesis of the central nervous system - the conditional gene inactivation approach

2 partners · 2 countries

Towards an understanding of carbohydrate recognition calcium-mediated - synthesis and studies of interactions of oligosacharides in cell-cell adhesion process

2 partners

Research of bis-specific inhibitors of telomerase - development of combinatorial synthesis and high throughput screening of oligonucleotide -peptide libraries

2 partners · 2 countries

The role of the tumour metastasis gene tiam1 in cell signalling and development

Molecular mechanisms of plzf-and pml-raralpha action in acute promyelocytic leukemia

2 partners · 2 countries

Functional studies on components of human nuclear domains which contain the acute promyelocytic leukaemia proto-oncoprotein pml

2 partners · 2 countries

New molecular biological approaches to evaluate the role of cell proliferation and cell death in liver cancer

2 partners · 2 countries

Functional analysis of the cdk inhibitor p21 and its regulation by cell cycle dependent degradation

2 partners · 2 countries

Functional studies of the acute promyelocytic leukemia proto-oncoprotein pml

2 partners · 2 countries

The role of ice proteases in myc-induced apoptosis

2 partners · 2 countries

Stereo and enantioselective synthesis of an anti-cancer agent modelled after the neocarzinostatin pharmacophore

2 partners · 2 countries

Synthesis of the c1-c28 fragment of spongistatin 1, a very potent antimitotic cancer cell growth inhibitor

2 partners · 2 countries

Mechanisms of action of calmodulin kinase ii on cyclin b degradation pathway in metaphase-arrested xenopus oocytes

2 partners · 2 countries

Subcellular and molecular mechanisms of apoptosis. Regulation by bc1-2 and proteases

2 partners · 2 countries

Identification of a tumor antigen recognized by autologous cytotoxic t lymphocytes on a human renal cell carcinoma

2 partners · 2 countries

Mouse models for analysing physiological defects caused by androgen receptormutations

2 partners · 2 countries

Structure-function analysis of e2f transcription factors

2 partners · 2 countries

Culture of normal human pigment cell progenitors

2 partners · 2 countries

Tamoxifen-inducible in vivo mouse system for studying p53 tumour suppression

2 partners · 2 countries

Regulation of transcriptional activators by the rb and mdm2 oncoproteins

2 partners · 2 countries