mutation

SynDrops · Understanding the physiological and pathological relevance of liquid-liquid phase separation by synuclein family of proteins

3-D Cardioid · Decoding enhancer usage and gene expression of human heart development in 3-D cardioids

Edit-hCOs · Precise Genome Editing to Correct Cardiomyopathies in Human Cardiac Organoids

2 partners · 2 countries

FBXW7-InReg · Defining the role of FBXW7 in intestinal epithelium regeneration

DeciphGYG · Deciphering the Molecular Mechanism of an Enzymatic Machinery for Glycogen Biosynthesis

HodgkINsights · Hodgkin Lymphoma: Insights from genomic studies of mutations in coding and non-coding regions

EGR · The role of genetic redundancy in adaptive evolution of efflux pumps

POLYGARCH · Impact of whole-genome duplications on the genetic and genomic architecture of adaptation

NECESSITY · New prECision thErapieS for uveal melanoma (targeting the Gαq/GNAQ oncogenic Signaling cIrcuiTrY)

2 partners · 2 countries

TITINmap · Towards Uncovering the Splicing Code of the Gigantic Gene Titin in Familial Dilated Cardiomyopathy

2 partners · 2 countries

DEEPCONSTRUCT · Understanding epigenetic inheritance and the structures of non-amyloid prion condensates using deep mutagenesis scans

RiboEscapers · A Riboescaper study: Protein synthesis driven by deficiently assembled ribosomes

Iso-Proline CTD · Hidden in plain sight: Masking RNA Pol II phosphorylation via proline isomerization during gene expression

PIPgen · PI3K/PTEN-related monogenic disease to understand cancer

11 partners · 5 countries

PROBYDE · Probing the bypassability of genetic constraints in drug-resistance enzymes

RET-TRAF · RET Trafficking

MITORett · Deciphering cerebellar mitochondrial alterations in Rett Syndrome

MUMDUPSC · Modelling undiagnosed muscular dystrophies using patients's stem cells

NotSOSTRESSED · The Neurobiology of Social Context-Dependent Stress Responses

GENMAINEVO · Genome maintenance and evolution

InMIND · Intervention in Neurodegenerative disorders via Mechanistic INsight into liquid-like Droplets

TxImmuneOrganoids · Divide and conquer: using patient-derived tumour organoids to dissect intra-tumour immune heterogeneity of non-small cell lung cancer

PERTURBATIONS · Large scale perturbations of the gene regulatory networks of E. coli

MechanoATR · ATR-mediated mechanotrasduction at the nuclear envelope