FP7Реинтеграция2011–2015

CHECKPOINT-INACT · NOVEL MECHANISMS INACTIVATING CHECKPOINT RESPONSE

7РП — „Хора“ (Действия „Мария Кюри“)

Период: 2011-11-01 → 2015-10-31
Финансиране от ЕС: 100 000 €
Участници: 1
Схема: MC-CIG

Линиите свързват координатора с партньорите.

Накратко на български

Механизмите, които клетките използват за разпознаване и поправяне на уврежданията в ДНК, са в центъра на това изследване. Разбирането им помага да се разбере как се защитава генетичната информация и как се предотвравя развитието на тумори.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

NOVEL MECHANISMS INACTIVATING CHECKPOINT RESPONSE

Checkpoint-INACT fully achieved its scientific objectives. Namely, the characterization of novel factors implicated in the DNA damage response, an essential player in protecting the genetic information in our cells and preventing cancer. During these four years, we understood how key players protecting the integrity of our genes work, revealing previously unknown mechanisms by which our cells respond to insults provoking changes in our genetic material. The results obtained create a framework for understanding the role of new factors in preventing tumour development. Checkpoint-INACT’s scientific results were made available to other scientists in numerous prestigious international meetings and were published in very prestigious scientific journals. Checkpoint-INACT has also allowed the researcher to establish his own independent laboratory, with the participation of several international researchers, and worked in close contact with other scientists at the Institute for Functional Biology and Genomics’ (IBFG) in Salamanca (Spain) and researchers at the Spanish National Research Council (CSIC). As a result, scientific skills and expertise obtained by the researcher during his career was transferred to the host institution and its environment. The project also helped establishing a number of collaborations with international research groups. Importantly, Checkpoint-INACT greatly helped the researcher in his career by contributing to his professional integration in Europe and to obtained permanent research position. Finally, Checkpoint-INACT’s research team participated in numerous to outreach activities aimed at bringing the importance of science and the scientific career to the general public. In these activities, the basics of cancer biology, science’s impact on daily life and scientific careers to the common people and to young university students. For more information please visit Checkpoint-INACT’s web page (http://ibfg.es/en/checkpoint-inact-en).

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Eukaryotic cells need to preserve the integrity of their genomes. Conditions resulting in increased genome instability, defined as the generation and amplification of mutations and chromosomal aberrations, are associated with cancer predisposition and human pathologies. The DNA damage checkpoint acts as a surveillance mechanism that safeguards genome integrity in response to genotoxic insults. While the processes leading to DNA damage checkpoint activation have been extensively studied, little is known about mechanisms mediating its inactivation, which is essential to restore normal cell physiology and overcome genotoxic insults.A genome-wide genetic screen performed by the research group identified novel Checkpoint Inactivating Factors (CIFs). These have been implicated in inactivation via proteolysis and subcellular sorting of several substrates but were previously not been implicated in the checkpoint response. Noteworthy, human orthologs of these factors have been involved in malignant transformation and cancer development.In this project genetic, genomic, molecular biology and proteomic approaches will be used to characterize the role of these novel CIFs in the cellular response to genotoxic insults. The project also aims at identifying and characterizing CFI’s targets within the checkpoint pathway. The research proposed will contribute to elucidate how eukaryotic cells revert checkpoint activation to maintain genome integrity, thus providing a framework for the development of new therapeutic agents.CIG funding will be invested in human resource in order to boost the project’s efficacy.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания