CPRESTSA-2005 · Cross-presentation of antigens by dendritic cells: mechanistic aspects of the cross-presentation of tumour specific antigens.
6РП — Действия „Мария Кюри“
- Период
- 2006-06-01 → 2008-09-30
- Финансиране от ЕС
- 258 545 €
- Участници
- 2
- Схема
- OIF
Линиите свързват координатора с партньорите.
Накратко на български
Дендритните клетки се изследват чрез микроскопия, за да се разбере как представят чужди антигени, като например тези от тумори от тип MAGE. Това помага за по-доброто разбиране на имунните реакции при рак, вирусни инфекции, ваксинации и автоимунни заболявания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
In vivo, cross-presentation of exogenous antigens has mostly been associated with dendritic cells. This process, which does not depend on the degradation of newly synthesized proteins, allows for the acquisition and presentation of peptides derived from exogenous antigens on MHC class I molecules. Better understanding of the mechanism of cross-presentation is essential, first because it appears crucial for priming CD8-positive T cell responses, and second because it has implications for various issues such as transplantation, viral infection, vaccination, autoimmune diseases and cancer. Recent reports have highlighted crucial aspects of the cellular mechanisms involved in cross-presentation. However, our understanding of this phenomenon remains incomplete. Here, we propose to study cross-presentation of exogenous antigens by confocal video microscopy and biochemical approaches, with a focus on the cross-presentation of tumour specific antigens of the MAGE-type. This study will be realized through a collaboration between two partners: the laboratory of Pr Cresswell in the Section of Immunobiology in Yale University Medical School, and the Cellular Genetics Unit of the Christian de Duve Institute of Cellular Pathology.
Оригинален текст от CORDIS (на английски).
Участници
- CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY · BRUXELLESКоординаторБелгия
- YALE UNIVERSITY SCHOOL OF MEDICINE · NEW HAVEN, CTСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз