OBESTATIN · OBESTATIN AS A REGULATOR OF ENERGY BALANCE: NEUROENDOCRINE TARGETS AND MOLECULAR MECHANISMS
6РП — Действия „Мария Кюри“
- Период
- 2007-05-01 → 2008-12-31
- Финансиране от ЕС
- 157 667 €
- Участници
- 2
- Схема
- OIF
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Обестатинът е протеин, който намалява приема на храна и телесното тегло при гризаците, действайки противоположно на грелина. Разбирането на тези механизми помага да се разбере как се регулира енергийният баланс и дали това е приложимо при хората.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Ghrelin is a 28aamino acid peptide derived from a prepropeptide of 117 residues, named pre-proghrelin. Very recently it was identified a new ghrelin-associated peptide encoded by a 23aamino acid peptide, with a flanking conserved glycine residue at the C terminus named obestatin. Obestatin showed a high affinity for GPR39 and needs an amidation to be biologically active. Regarding its physiological effects, obestatin is able to antagonize ghrelin effects on food intake, body weight and gastric emptying, but had no effect on growth hormone levels. Intraperitoneal and intracerebroventricular injection of obestatin suppressed food intake in a time- and dose-dependent manner. In contrast, treatment with the non-amidated obestatin was less effective. The fact that the same precursor leads to two different peptides with orexigenic and anorexigenic actions shows us that energy balance depends not only of the expression of different peptides but also the rate of transcription from the precursor to aSleana or aSfata gene is very important. As it is typical when a new discovery appears, numerous unanswered questions arise and further studies will be necessary to find those answers. For instance, even obestatin decreased the food intake and body weight in rodents, serum leptin levels were not affected after treatment with obestatin, suggesting minimal modulation of body-fat content. Moreover, fasting did not change serum obestatin levels and circulating levels of obestatin are much lower than ghrelin, thus the relevance of endogenous obestatin remains unclear. Finally, from a pharmacological point of view, the most interesting will be to check if obestatin changes the food intake or the body weight in humans.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSIDADE DE SANTIAGO DE COMPOSTELA · SANTIAGO DE COMPOSTELAКоординаторИспания
- UNIVERSITY OF CINCINNATI OBESITY RESEARCH CENTRE · CINCINNATIНиво градСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз