TCR-PMHC RECOGNITION · Structural and functional analysis of virus specific TCR-pMHC recognition
6РП — Действия „Мария Кюри“
- Период
- 2007-03-01 → 2009-09-30
- Финансиране от ЕС
- 204 966 €
- Участници
- 2
- Схема
- OIF
Линиите свързват координатора с партньорите.
Накратко на български
Връзката между структурата на Т-рецепторите и разпознаването на вирусни протеини се анализира чрез примери с грип при мишки. Разбирането на тези процеси помага при разработването на ваксини срещу ХИВ, хепатит С и грип А.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The proposed research plans to understand the relationship between structural requirements for TCR/peptide/MHC interactions and their influence on TCR repertoire diversity given it has been reported that increased T cell repertoire diversity correlates with increased resistance to viral infection. While the structural characteristics of TCR/peptide/MHC interactions can be elucidated, a large question that remains is how these factors influence the function of virus-specific CTL generated after infection. This proposal aims to first study the molecular interactions that define specific TCR recognition of both DbNP366 and DbPA224 complexes (respiratory infection of C57BL/6J (H-2b) mice with influenza A viruses induces CD8+ T cell responses specific for epitopes derived from nucleoprotein amino acid 366-374 and acidic polymerase amino acid 224-233 with structural and functional differences). The second aim utilises a retroviral transduction system to ectopically express TCRs of known specificity. This will facilitate the analysis of functional characteristics of these transduced T cells after infection. In this way, this proposal will link the structural aspects of TCR recognition of peptide/MHC complexes and the in vivo consequences these interactions have on the responding T cell repertoire. These studies will provide a rationale for vaccine design human viral pathogens such as HIV, Hepatitis C and Influenza A virus.
Оригинален текст от CORDIS (на английски).
Участници
Връзки
Данни: CORDIS, © Европейски съюз