MOBODICT · Noninvasive Monitoring of Blood Flow and Oxygen Dynamics as Biomarkers in Cancer Tumours
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2012-03-01 → 2014-02-28
- Финансиране от ЕС
- 168 896 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Оптичните техники за измерване на кръвния поток и кислорода се използват за проследяване на промените в туморите, например при рак на бъбрека. Това помага за по-доброто разбиране на действието на терапиите и ранното откриване на устойчивост към лечението.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Noninvasive Monitoring of Blood Flow and Oxygen Dynamics as Biomarkers in Cancer Tumours
Diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) are optical techniques that can be used to study haemoglobin concentration, oxygenation and blood flow in biological tissue non-invasively and in vivo. In this project we use these techniques to study physiological changes in tumours. In particular; • We have developed a non-contact system to study of experimental therapies on xenoimplanted tumours in mice allowing for monitoring of physiological changes in them due to therapy without the need to sacrifice animals at several time-points. • We have development and used a Monte Carlo package for light transport simulations to aid the analysis and design of the optical systems. The code is particularly designed to allow simulation of both DCS and broadband or time-resolved DOS in arbitrary geometries, e.g. from MRI, and will be publicly available for other research groups when finished. • We used these tools to study of antiangiogenic therapy on renal cell carcinoma in mice to obtain important insight in the mechanics of antiangiogenic therapy and be able to detect therapy resistance early-on. • Finally, we have explored the utility of these techniques in superficial cancers in the neck region.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Cancer is one of the leading causes of death in the world, taking an enormous toll on the society. Early detection is paramount for effective treatment. Afterwards, to individualize and optimize the treatment regime, it is increasingly becoming evident that early and frequent monitoring of the evolution of the tumour physiology in response to treatment is needed. Optical tools are emerging as promising modalities to this end. We will take advantage of this ability to carry out a pilot study to investigate the possibility of extending the use of diffuse optical methods to aid thyroid cancer characterization and therapy monitoring. Thyroid nodules are very common (~27% in adults) and a considerable amount of these, about 5%, develop into cancers. Unfortunately, the sensitivity and specificity of currently used technique for detection of potentially malignant nodules, thyroid ultrasound (US)-guided biopsies, is poor, making diagnosis and treatment difficult. We believe that optical methods will improve this. Furthermore, malignant tumours usually attract the formation of new and chaotic blood vessels via a complex process called angiogenesis. This has been exploited by the development of numerous treatment methods that rely on the inhibition of angiogenesis. However, it has also been observed that despite initial successful inhibition of angiogenesis, tumours may adapt and regain angiogenesis so that they can grow again. We will investigate this onset of tumour resistance by developing a novel, new 3D optical scanner for diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) in mouse models. If we are successful, we would advance the frontiers on basic understanding of cancer biology and explore new clinical applications of optical technologies.""
Оригинален текст от CORDIS (на английски).
Участници
- FUNDACIO INSTITUT DE CIENCIES FOTONIQUES · CastelldefelsКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз