HEART PATCH · Development of a Bioengineered Heart Patch for the Treatment of Myocardial Infarction
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2012-08-01 → 2016-07-31
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Биоинженерните сърдечни пластини се разработват чрез създаване на композитни материали с висока механична здравина. Те могат да помогнат за лечението на хора, претърпели инфаркт на миокарда.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Development of a Bioengineered Heart Patch for the Treatment of Myocardial Infarction.
The main objective of the project was to develop a bioengineered heart patch for the treatment of Myocardial Infarction. Significant scientific advances were made through this project toward the development of a heart patch from August 2012 till now. For instance, composite biomaterial scaffolds were made and comprehensively tested for physical properties such as for mechanical robustness. The composite materials were found to be mechanically stronger than the non-composite ones. This project could make a great impact on the European societies as well as toward the health of individuals who suffer from heart diseases. The CIG grant made researcher’s transition from Canada to Sweden much easier and provided him with an initial funding to start establishing his research career in Sweden by enabling him to start his group by hiring a talented postdoctoral fellow from Australia and purchasing raw materials, some lab supplies, and equipment for implementation of the project and gaining relative independency. Having said that, it is very unfortunate that the project had to be terminated early and placed on hold after several months due to the lack of funding.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Background: Cardiovascular diseases (CVD), e.g. Myocardial Infarction (MI) and stroke, are the leading cause of death, accounting each year for more than 17.5 million people worldwide, 25% of which is in Europe. Cardiac bioengineering is a new research area to develop grafts and patches to replace or repair damaged heart tissue. However, a fully functional graft has not yet conceived. The main goal of this project is to develop bioengineered heart patches to induce regeneration of the tissue and restore heart functions after MI.Aims: the aims and the results hoped for are:1. To develop collagen-based nano-fibrous scaffolds that are:a. Biocompatible and biodegradable, e.g. favour cell growth, and allow regeneration of thehost tissue and remodel with the growing heart.b. Robust, elastic, and contractile that matches heart muscle.c. Conductive to electrical impulses generated by the heart.d. Porous enough to enable exchange of nutrients and waste from the patch.e. Non-thrombogenic to ensure the patch will not cause thrombosis.2. To significantly reinforce the biomedical research in Europe through efficient use of the allocated budget toward my integration into a more permanent position in Sweden, as well as enhancing knowledge transfer and cooperation between EU and Canada.Research Strategy: I have previously developed hybrid interpenetrating polymer networks (HIPN) as bioengineered corneas that were mimetic of the natural cornea and successfully implanted into corneas of pigs with seamless host-graft integration and regeneration of the host cornea. HIPN is a core concept that can be tailored for various tissue applications. I therefore propose to engineer HIPN scaffolds for cardiac patches mainly comprised of collagen, and carbon nanotubes. I joined Linkoping University in March 2011 as an Assistant Professor from Canada. My expertise in tissue engineering combined with expertise of the host in Nanobiotechnology is an excellent match for this project.
Оригинален текст от CORDIS (на английски).
Участници
- Linköping University · LinköpingКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз