SOX-BMI1 · Role of SOX9-BMI1 in adult neural stem cells and in glioma stem cells
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2012-10-01 → 2016-09-30
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Взаимодействието между протеините SOX9 и BMI1 се изучава при нормални стволови клетки на мозъка и при агресивни тумори (глиобластома). Разбирането на този механизъм помага за изясняване на биологията на рака и разработването на по-ефективни стратегии за лечение.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Role of SOX9-BMI1 in adult neural stem cells and in glioma stem cells
Cancers display remarkable phenotypical and functional intratumoral heterogeneity. The discovery of a rare subpopulation of tumor cells that acquired stem cells properties or originate from stem cell transformation in several malignancies has profound implications for cancer therapy, as these cells are responsible for the origin, progression and recurrence of the tumors. Glioblastoma multiforme is one of the most aggressive and lethal human malignancies where the cancer stem cells have been identified. However, this research is not translated into significant advances in therapy treatment. The therapeutic protocols present very low success rate and the average survival for patients do not exceed a year and half of life. Factors involved in establishing and maintaining stem cells of normal tissues are activated as part of the tumorigenic process. These stem cell factors are likely to be important for maintaining the characteristics of cancer stem cells. The study of the function of stem cell factors appears to be essential for understanding the biology of glioblastoma and designing effective therapeutic strategies. SOX9 and BMI1 are essential in multiple processes during embryonic development and regulate the population of stem cells in various tissues including the brain. Both are overexpressed in a wide range of cancers, mainly in tissues where they plays critical roles in stem/progenitor cells. Our group has recently identified that BMI1 is a downstream target of SOX9. The ultimate goal of this translational research project was investigate the clinical relevance of SOX9-BMI1 pathway, characterize its role in the regulation of cancer stem cells and determine whether their overexpression is sufficient to promote cell transformation. To achieve our aims, we have generated a unique set of cellular and animal models to study in vitro and in vivo the biology of adult and cancer stem cells.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Cancers display remarkable phenotypical and functional intratumoral heterogeneity. The discovery of a rare subpopulation of tumor cells that acquired stem cells properties in several malignancies has profound implications for cancer therapy. These cells are suppose to be responsible for the origin, progression and recurrence of the tumors. Thus, new strategies directly targeting cancer stem cells should be important for cancer treatment. Glioblastoma multiforme, the most common and malignant brain primary cancer, present very low success rate in the actual therapeutic protocols and the average survival for patients do not exceed a year of life. This can be partially explained because they contain a population of glioma stem cells.Factors involved in establishing and maintaining stem cells of normal tissues are activated as part of the tumorigenic process. It is likely that these stem cell factors are important for providing and maintaining the characteristics of cancer stem cells. SOX9 and BMI1 are transcriptor factors essential in multiple processes during embryonic development and in the regulation of stem cells in various tissues including the brain. Both are often overexpressed in cancer, mainly in tissues where they plays critical roles in stem/progenitor cells. Our group has recently identified that BMI1 is a direct downstream target of SOX9. The goals of this translational research project is investigate the clinical relevance of SOX9-BMI1 in glioblastoma, characterize its role in the regulation of glioma stem cells and determine whether Sox9-Bmi1 concomitant overexpression is sufficient to induce neural stem cell transformation and cause gliomas. To achieve our aims, we will generate a unique set of cellular and animal models to study in vitro and in vivo the biology of neural and glioma stem cells
Оригинален текст от CORDIS (на английски).
Участници
- ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOGIPUZKOA · DONOSTIA-SAN SEBASTIANКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз