UCNANOMAT4IPACT · Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2013-01-15 → 2017-01-14
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Наночастици с възможност за преобразуване на светлината се използват за активиране на противотуморни лекарства на база платина и рутений. Това позволява използването на инфрачервена светлина, която прониква по-дълбоко в тъканите и причинява по-малко увреждания от стандартните методи.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy
The project has investigated the use of upconverting nanoparticles (UCNPs) as photoactive nanoplatforms for the light-activation of metal-based anticancer prodrugs. The unique optical properties of upconverting materials allow using near-infrared light excitation sources to transform metal-based prodrugs in biologically active species. At such wavelength range, light achieves better tissue penetration and causes less damages to biological tissues. The project has demonstrated that the adopted strategy was successful and Pt and Ru anticancer agents could be photoactivated with 980-nm light. New synthetic approaches were developed within UCnanomat4iPACT to functionalize the surface of UCNP nanoparticle and carry metal-based prodrugs. In the project, the photochemistry of hybrid UCNP-metal complex nanoconstructs was investigated in solution and physiological-like conditions. Furthermore, biocompatibility studies performed in our laboratories on UCNP materials functionalized with phosphonates showed that they are suitable for applications in tissues, whereas imaging experiments indicated they are good MRI T1-contrast agents and that UCNPs can be employed as nuclear imaging probes to study biodistribution in vivo. Albeit results obtained in the project demonstrate UCnanomat4iPACT approach is promising, improvements in the light upconversion efficiency of UCNPs, as well as their design as delivery platforms, must be pursued for application in advanced preclinical settings. The capacity of employing near infrared light as excitation sources expands the potential of metal-based PACT prodrugs, which rarely can be activated at convenient wavelengths for photochemotherapy. Project website: https://lucasalassa.wixsite.com/salassa
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds studied as novel photochemotherapy agents. UCNP-mediated NIR activation will allow overcoming metal complexes’ light absorption limitations, simultaneously achieving considerably higher tissue penetration and preserving photochemical reactivity. Indeed, the rich photochemistry of metal complexes can result in unique cell killing modes, critically important in the development of novel anticancer prodrugs.The project aims at investigating the use of UCNPs in the photoactivation of promising anticancer metal complexes, and more specifically at developing new nanomaterials where these two components are integrated to give a superior prodrug. Anchoring photoactive anticancer coordination compounds on UCNPs can produce materials with optimal photophysical and photochemical properties for chemotherapy. Moreover, the chemical versatility of UCNPs offers opportunity for functionalization with biological vectors, which improve biocompatibility, targeting and selectivity features of these integrated nanomaterials in cells and tissues. Remarkably, UCNPs are also excellent new candidates for multimodal (optical/MRI/PET) bioimaging. Their upconverted luminescence, magnetic resonance relaxivity and radioactivity (ease of 18F-labeling) will serve to visualize fundamental biological events with high spatial resolution, which are key to study the photoactive nanomaterials’ anticancer action as well as for their medical use. All such features combined together have the potential to deliver innovative therapeutic and imaging agents for cancer phototherapy.
Оригинален текст от CORDIS (на английски).
Участници
- ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE · San SebastianКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз