Motor_Dev · Sensory feedback in the development of motor cortex: underlying physiological network mechanisms and its relation to epileptic discharges
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2013-05-01 → 2015-04-30
- Финансиране от ЕС
- 194 047 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Сензорната обратна връзка при новородени плъхове показва как спонтанните движения влияят върху развитието на моторната кора и гръбначния стълб. Разбирането на тези механизми помага да се разбере връзката между развитието на нервната система и епилептичните разряди.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Sensory feedback in the development of motor cortex: underlying physiological network mechanisms and its relation to epileptic discharges
• Scientific summary Integration of motor and somatosensory functions is a primary requirement for body movement control and exploration (Llinas, 2001). Motor and somatosensory systems develop and bind together to support sensorimotor integration (Arber, 2012) Early stages of sensorimotor system development are characterized by the occurrence of spontaneous movements. Whether and how these movements support coordination in developing sensorimotor circuits remains unknown, however. Part I. Using translaminar recordings from the spinal cord of neonatal rats in vivo, we found highly correlated activity in sensory and motor zones, provided by movement-related bursts in motor zones that were followed by bursts in sensory zones, suggesting a potential involvement of sensory feedback and efferent copy. Deafferentation did not affect activity in motor zones and movements, but profoundly suppressed activity bursts in sensory lamina and resulted in almost complete sensorimotor uncoupling, implying a primary role of sensory feedback in sensorimotor integration. This was further supported by largely dissociated activity in sensory and motor zones observed in the isolated spinal cord preparation in vitro. Thus, sensory feedback resulting from spontaneous movements is instrumental for coordination of activity in developing sensorimotor spinal cord circuits. Part II. Through simultaneous recordings of primary motor cortex (M1) activity and motor behavior in neonatal rats, we found so far that, over the first postnatal week, spontaneous hindlimb movements trigger spindle-bursts in the corresponding area of the contralateral M1. At these ages, epileptiform discharges, induced by local delivery of bicuculline, in M1 also were driven by spontaneous movements. From the second postnatal week, spontaneous movements and M1 spindle-bursts waned in parallel with the development of continuous background activity, and local bicuculline-induced M1 epileptiform discharges started driving contralateral hemiclonic jerks. Thus, during the first postnatal week, M1 operates essentially in a somatosensory mode, with sensory feedback resulting from spontaneous movements triggering topographic spindle-bursts that are potentially involved in the activity-dependent formation of sensorimotor circuits. Epileptiform discharges in M1 cortex during the neonatal period remain largely infraclinical.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Early in development, spontaneous bursts of activity at the level of the spinal cord trigger spontaneous twitches of corresponding groups of muscles fibres. Twitching provides sensory feedback that generates specific neuronal oscillations in somatosensory cortex. The proposed project will address, in first line, if sensory feedback provided by spontaneous muscle twitches evokes specific patterns of neuronal activity in motor cortex. This could occur via functional projections arising from somatosensory cortex and/or thalamic nuclei, which have been demonstrated in adults. These activity patterns will be studied as substrates for the development of motor cortex, and their developmental changes will be characterized in relation to the formation of its main output, the corticospinal tract, and developmental twitching elimination. In addition, the proposed project will address if under pathological conditions, spontaneous muscle twitches trigger epileptic discharges in motor cortex. It is anticipated that such discharges are asymptomatic prior to, but are manifested by epileptic jerks upon the formation of the corticospinal tract. Using a combination of cutting-edge electrophysiological and imaging techniques, in vivo, the results are expected to provide the first insights on if and how peripheral stimuli induce the expression of neuronal oscillations in the developing motor cortex, and on how this may guide its maturation. Moreover and of great clinical importance, the results will provide a mechanistic explanation for the phenomenon of electroclinical uncoupling in neonatal epilepsy.
Оригинален текст от CORDIS (на английски).
Участници
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз