BLADDER CANCER EPID · Nutrition and Bladder Cancer
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2013-09-01 → 2017-08-31
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Връзката между храненето и рака на пикочния мехур се анализира чрез данни за конкретни храни и хранителни режими. Разбирането на тези влияния може да помогне за намаляване на заболеваемостта, смъртността и разходите за здравеопазване.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Nutrition and Bladder Cancer
Background: Bladder cancer is the most expensive malignancy to treat from diagnosis until death, and is the 7th most common cancer worldwide. As is the case for many types of cancer, the development of bladder cancer is likely to be influenced by diet. The role of diet in bladder cancer could be particularly pronounced because the bladder is an excretion organ. It has been indicated that one-third of all bladder cancer deaths could have been prevented by dietary modifications. Efforts towards the prevention of bladder cancer by dietary recommendations could therefore lead to a substantial reduction of morbidity, mortality and healthcare costs. This study aims to increase the understanding of the influences of foods, nutrients and dietary patterns combined on the prevention of bladder cancer by bringing together the world’s data on this topic. Method/Design The BLadder cancer, Epidemiology and Nutritional Determinants (BLEND) study was set up with the purpose of collecting individual patient data from observational studies on diet and bladder cancer. BLEND includes data of 18 case-control and 6 cohort studies on diet and bladder cancer, from 12 different countries across the world (i.e Belgium, Canada, China, France, Germany, Japan, Italy, United Kingdom, USA, Spain, Sweden and Taiwan), representing data for 11,261 bladder cancer cases and 675,532 controls. Homogenization of the dietary data was done by making use of a Eurocode 2 Core classification version 99/1 based codebook. Besides dietary data, BLEND also has data on ethnicity, TNM classification of malignant tumor, smoking status, smoking frequency and duration and family history. Results Currently, our analyses on single food items are still ongoing, although preliminary results will be presented confidentially in this report. The first definitive results on the adherence to the Mediterranean Diet show an inverse effect of high versus low adherence to the Mediterranean diet and bladder cancer risk (OR: 0.90 [95% CI 0.80, 0.99]). This result was even more pronounced among women with a non-muscle-invasive type of bladder cancer (OR:0.75 [95% CI 0.55, 0.96]). Discussion The large number of cases included in this study, resulting in much statistical power, will enable us to provide further evidence for the current dietary recommendations for the prevention of bladder cancer. More information can be found on: http://dietandbladdercancer.org/ Contact details: Anke Wesselius, PhD: anke.wesselius@maastrichtuniversity.nl
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
During the last decade I have built a research line on bladder cancer epidemiology with a specific emphasis on diet. This has led to 54/150 publications on this topic. Although, the literature is sparse, my team and others have concluded that some micronutrients in the diet such as vitamins C, E and selenium may play a preventive role in bladder carcinogenesis. We are currently pursuing this lead with two chemoprevention clinical trials, two case-control and one cohort study. Although other food products have been researched, so far the results remain inconclusive.Our 2008 expert report for the World Health Organization concluded that the accumulated evidence on the association between specific foods, nutrients, dietary patterns and the risk of bladder cancer is still weak. This is surprising as diet is expected to play an important role in carcinogenesis because the bladder is an excretion organ. The most likely reason for this is that most previous studies have had insufficient sample size and thus lacked adequate statistical power for analyses on 1) individual food items instead of the more common but less detailed food groups, 2) for subgroup analyses and 3) for food-food interactions.The proposed research brings together the world’s data on diet and bladder cancer. In a unique collaboration, researchers from 26 case-control studies and 15 cohort studies across the world have agreed to share their nutritional data with over 30.000 participants including over 10.000 bladder cancer patients.The project aims to provide definite answers on which individual food products, nutrients, existing diets (both regionally and culturally defined) and adherence dietary recommendations could influence bladder cancer risk. In addition, contemporary principle components and machine-learning algorithms will be used to identify novel explanatory dietary patterns. The results will be used to update existing dietary recommendations for the prevention of bladder cancer.""
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITEIT MAASTRICHT · MaastrichtКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз