TOXKINBIO · Toxicokinetics and biotransformation in aquatic invertebrates
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- 2014-03-01 → 2018-02-28
- Финансиране от ЕС
- 100 000 €
- Участници
- 1
- Схема
- MC-CIG
Линиите свързват координатора с партньорите.
Накратко на български
Процесите на усвояване, преработка и изхвърляне на лекарства се проучват при охлюви, скариди и води бълхи. Това помага за по-добра оценка на рисковете за екосистемите и създаването на по-щадящи околната среда медикаменти.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Toxicokinetics and biotransformation in aquatic invertebrates
Overall the project the developed an integrated experimental-modelling strategy for the study of toxicokinetics and biotransformation patterns across different species enabling ultimately a more comprehensive and quantitative prediction of the effects of chemicals on ecosystems health. In particular, the project built this strategy upon a matrix of three aquatic invertebrate model species by four selected chemicals relevant to freshwater systems and compared biotransformation pathways and other toxicokinetic processes twelve chemical-organism combinations for models parameterisation. This work improved our understanding of hwat happens to pharmaceuticals in the environment. We learned about how different freshwater species (a snail, a shrimp and water flea) take up pharmaceuticals, metabolise and transfrom them and then excrete them. The main finding is that there are surprisingly big differences between the species. Also we found that some pharmaceuticals are metabolised a lot and others much less so. This helps to assess the risks of pharmaceuticals in the environment and can inform design of environmentally friendly drugs. Thus it is of interest to industry and policy makers.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Pesticides, pharmaceuticals and other chemicals support our modern standard of life, but their use can have detrimental impacts on our environment. We want to study the uptake, biotransformation and elimination (toxicokinetics) of pharmaceuticals in aquatic invertebrates. We aim to identify and model biotransformation pathways in four different species. Studying the comparative toxicokinetics of small, aquatic invertebrates is of great interest because it contributes to understanding evolutionary and environmental mechanisms and causes of differences in species sensitivity to chemicals.We want to apply a cutting edge analytical method to discover and quantify biotransformation products and pathways of pharmaceuticals (Ibuprofen, Fluoxetine, Carbamazepine, Venlafaxine) in small aquatic invertebrates (Daphnia magna, Chironomus riparius, Hyalella azteca, Lymnaea stagnalis).We selected pharmaceuticals which are frequently detected in aquatic systems, have known adverse effects on aquatic invertebrates and are metabolised in humans. Test organisms are cultured and were selected based on their importance in chemical testing (ecotoxicology) as well as their diversity in respiratory strategy and phylogeny.Extracts of exposed and control organisms are analysed using high resolution mass spectrometry complemented by expert systems for the prediction of transformation pathways and products. We will carry out toxicokinetic experiments where we measure concentrations of parent compound and biotransformation products in the organism at different times during the experiment. A pulsed exposure design ensures efficient measurement and calibration of the toxicokinetic model consisting of a set of differential equations. We hope to find novel biotransformation pathways and will search for patterns in toxicokinetic parameters. Toxicokinetic differences between species will help to understand sensitivity to synthetic chemicals and quantify the importance of biotransformation.""
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF YORK · YORK NORTH YORKSHIREКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз