MICARTREGEN · Multi-biofunctional implants for in-situ cartilage regeneration for traumatic and early osteoarthritic lesions
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- —
- Финансиране от ЕС
- 231 283 €
- Участници
- 1
- Схема
- MC-IEF
Линиите свързват координатора с партньорите.
Накратко на български
Нов вид имплант без клетки стимулира възстановяването на хрущялни увреждания, причинени от травми или ранен артрит. Той привлича стволови клетки от ставата и ги превръща в хрущялни клетки, за да се възстанови тъканта.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
MICartRegen is a multidisciplinary and highly innovative project aimed at designing and producing a novel multi-biofunctional, cell-free prototype orthopaedic implant able to induce, stimulate and sustain self-repair of injured cartilage tissue. This implant would be used to promote the in-situ regeneration of functional articular cartilage in lesions caused by trauma and early stage osteoarthritis. The proposed implant is novel, cell-free and differs in its mode of action from other devices on the market.In brief, the implant will contain a) Bioactive molecules to recruit and retain ""repair cells"" (mesenchymal stem cells) from the joint fluid or released by the orthopaedic surgeon by subchondral drilling; b) Bioactive factors to promote maturation of the recruited stem cells into cartilage cells (chondrocytes) to produce the required extracellular matrix components. The technologies used to fabricate the prototype implant are adaptable, therefore custom fabrication of sophisticated bioactive scaffolds for different biomaterials containing various bioactive factors would be possibleThe success of the project relies on the strong background in biomaterials science, largely in bio-functionalisation and genetic activation of materials, of the candidate, combined with complimentary skills and infrastructure of the host.MICartRegen will also give the candidate an opportunity to be trained in new methods on biological evolution of biomaterials, and transferable skills that will greatly boost her career. Furthermore, it will help her to become an independent and experienced researcher able to plan and manage her research, disseminate the results, up to industrial exploitation, through participation in courses and cooperation with experienced scientists.""
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY OF SHEFFIELD · SHEFFIELDКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз