BIONANOSMART_DDS · Biopolymer-Based Nanoparticle “Smart” Drug Delivery Systems and their Biopharmaceutical Application by Oral Administration
7РП — „Хора“ (Действия „Мария Кюри“)
- Период
- —
- Финансиране от ЕС
- 7500 €
- Участници
- 1
- Схема
- MC-IIFR
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Наночастици от природни захари се тестват като „умни“ контейнери за транспортиране на лекарства през устата. Тези системи помагат да се разбере как температурата и pH нивото влияят върху освобождаването на терапевтични молекули в организма.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
This initiative aims to gain both fundamental understanding and applied knowledge on novel polysaccharide-based nanoparticles to be utilized as ‘smart’ advanced delivery systems of therapeutic biomacromolecules for oral administration. To this end, nanoparticles will be harnessed from chitosan and other polyionic polysaccharides of biomedical use, cross-linked with a natural non-toxic biocompatible agent. Sensitivity to changes in temperature and pH will be conferred by modifying the surface charge (zeta potential) by modifying the local hydrophilic/hydrophobic balance the nanoparticle surface. While sensitivity towards two biomolecules of therapeutic significance will be achieved by modifying the nanoparticle surface by molecular imprinting, using a non-covalent approach. Phase transitions in these systems will be investigated by means of biophysical techniques including dynamic light scattering and SAXS (small-angle X-ray scattering). The adsorption capacity and selectivity of the molecularly imprinted surface will be studied by quartz crystal micro balance with dissipation mode (QCM-D) techniques. The in vitro release profile will be evaluated as a function of the presence of the external stimuli (temperature, pH and concentration of specific molecules). Citotoxicity and cell uptake will be evaluated in Caco-2 cell monoculture and the biopharmaceutical performance will be evaluated for selected prototypes after oral administration in a rat model.
Оригинален текст от CORDIS (на английски).
Участници
- Centro de Investigacion en Alimentacion y desarrollo · La VictoriaКоординаторНиво градМексико
Връзки
Данни: CORDIS, © Европейски съюз