H2020Докторантска мрежа2015–2018

AdapTT · Real time therapy planning for Thermal based therapy modalities in oncology care.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-01-01 → 2018-12-31
Финансиране от ЕС: 766 123 €
Участници: 3
Схема: MSCA-ITN-EID

Линиите свързват координатора с партньорите.

Накратко на български

Термалната аблация на чернодробни тумори чрез радиочестотни вълни се анализира чрез нови биофизични модели. Това помага за по-точно поставяне на иглата и по-добро планиране на лечението в реално време, което намалява рисковете и времето за възстановяване на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Real time therapy planning for Thermal based therapy modalities in oncology care.

Motivation Assisting Minimally Invasive Cancer Treatments Minimally invasive procedures have been gaining ground in recent years, due to the many advantages they offer by reducing the operation costs, the patients recovery time and discomfort and the risk of side-effects and infection. For the purposes of this project we focus on thermal based ablation of hepatic lesions. In particular we aim at improving the planning and guidance tools for radio-frequency based ablation treatments, by providing information to the physician, such as the optimal placement of the needle and the outcome of the ablation, prior and during the operation. Objectives 1. Development of a multi-scale biophysics model, which accounts for the cooling effect caused by blood vessels during RF ablation. The model should be accurate and fast enough for clinical use.. 2. Improving the accuracy and effectiveness of ablation treatments, by developing reliable and computationally efficient optimization routines, which can be used not only for pre-operative planning, but also during the treatment. 3. Development of reliable experimental validation methods for the above described numerical models. The validation can rely either on the measurement of temperature fields or on the assessment of the size of the ablation zones. An ultimate goal, of this experimental part would be a real-time feedback to the planning tool to enable an adaptive therapy.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

AdapTT will unlock the potential for development of a real time adaptive therapy planning tool for thermal treatment in prostate oncology. Highly specialized and cost effective state-of-the-art scientific solutions can only be developed when complimentary partners of different sectors work synergistically. The intersectoral nature of the European Industrial Doctorates (EID) framework, between industry and academia, is a key requirement for success of the proposed PhD projects. Specific application knowledge on clinical software platforms development, imaging systems and therapy modalities of the industrial partner, has to be combined with fundamental biophysical knowledge and clinical need insights of the clinical academic partner. This combination of European based expertise is unique and being able to be exposed to these different research climates will strongly enhance the employability and career prospects of the early stage researchers (ESR’s), participating in the program. The objectives of AdapTT are: 1. To train and to deliver a cohort of young researchers experienced in transcending traditional research boundaries to deliver deeper insight into energy dose delivery of thermal therapy modalities such as high intensity focused ultrasound (HIFU), microwave, laser and radiofrequency (RF) in soft tissue; 2. To discover and leverage deep understanding of the molecular, cellular and biophysical impact of temperature on tumour cell behaviour and healthy soft tissue properties;3. To develop a therapy planning tool, based on a combination of pre-clinically validated 3D energy dose delivery biophysics models and mathematical algorithms to enable real time energy monitoring and real time energy delivery adaptation;4. To significantly impact EU competitiveness by bringing leading science- and technology experts together to work on basic- and translational problems from both academic and industrial viewpoint.

Оригинален текст от CORDIS (на английски).

Участници

PHILIPS ELECTRONICS NEDERLAND BV · EindhovenКоординаторНидерландия
TECHNISCHE UNIVERSITEIT EINDHOVEN · EindhovenНидерландия
UNIVERSITAETSKLINIKUM AACHEN · AachenГермания