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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2015–2018

BonePain · European Training Network on Bone Pain

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2015-01-01 → 2018-12-31
Финансиране от ЕС
3 558 676 €
Участници
8
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Механизмите на костната болка, като тази при артрит или фрактури, са в центъра на изследванията. Разбирането им помага за разработването на по-добри лекарства за милиони хора с двигателни нарушения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

European Training Network on Bone Pain

Musculoskeletal disorders are the second greatest cause of disability in the world, and a large part of the disability is due to bone pain. In Europe 20-30% of adults are affected at any one time by musculoskeletal pain such as arthritis pain, lower back pain, pain from osteoporotic fractures and bone metastasis. An intensified effort is warranted to overcome this huge societal challenge by elucidating the mechanisms of musculoskeletal pain and providing better treatment. To address this societal challenge and the strong innovation potential, the BonePain training network has created the first European platform to promote frontline research, innovation and education within bone pain. The network consisted of 5 academic and 2 industrial beneficiaries as well as 1 industrial partner and 2 academic partners, all committed to creating an outstanding training program for early stage researchers to elucidate the mechanisms of bone pain and develop new medicines. The overall objectives of the BonePain training network were to train early stage researchers to become highly skilled and innovative researchers and provide them with expertise that will enable them to gain high level employment both in academia and industry. Through integrated research projects they would address key questions related to bone pain and push forward the field towards better treatment for the millions of Europeans suffering from bone pain.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The aim is to create an innovative European PhD training network in bone pain. Millions in Europe and beyond suffer from bone pain, a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. However, being a truly multidisciplinary subject spanning neuroscience, bone biology, and even cancer research, it demands a multidisciplinary approach. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is available. To address this societal challenge and the strong innovation potential, we want to form the first European platform to promote frontline research, innovation and education within bone pain. The network encompasses 5 academic and 2 industrial beneficiaries and 1 industrial partner all committed to creating an outstanding wide-ranging yet integrated training program for early stages researchers to elucidate the mechanisms of bone pain and develop new medicines. We will use in vivo models of arthritic pain, cancer-induced bone pain and fracture pain to investigate the pathophysiology and novel treatment strategies. In vivo electrophysiology will be used for studying the physiology and pharmacology of pain transmission and its modulation. Transgenic mouse models will be used to tease out the specific neuronal receptor subtypes involved. Sophisticated behaviour tests will evaluate response to novel treatments. We will create a biobank of human cancer-infiltrated bone to identify specific patterns of neuronal receptor expression and to validate therapeutic targets in humans. In an extensive training effort covering both specific research skills and transferable skills, the students will obtain an interdisciplinary, state-of-the-art and innovative training from the participants, several of which have experience from international networks. The students will benefit from secondments with industrial partners and with some of the foremost pain researchers in Europe

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз