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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2015–2018

InCeM · Research Training Network on Integrated Component Cycling in Epithelial Cell Motility

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2015-01-01 → 2018-12-31
Финансиране от ЕС
3 866 665 €
Участници
29
Схема
MSCA-ITN-ETN

Линиите свързват координатора с партньорите.

Накратко на български

Механизмите на движение на епителните клетки се анализират чрез математически модели и нови методи за запис, за да се разбере как се формират тъканите или се разпространяват туморите. Тези знания помагат за подобряване на диагностиката и лечението на рак и хронични рани.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Research Training Network on Integrated Component Cycling in Epithelial Cell Motility

Cell migration (cell motility) is fundamental for the functioning of the human body. It is crucial for tissue formation and maintenance and is needed for wound healing. Cell migration is also essential for tumour invasion and metastasis during carcinogenesis. The underlying processes for cell migration are poorly understood at the mechanistic and regulatory level because of its complexity involving multiple cellular systems that are regulated through genetic, physical and biochemical signals. Yet, an integrated view is urgently needed for predicting and manipulating cell migration as a pivotal process in both health and disease. This knowledge is expected to open new avenues for the diagnosis of human diseases, their treatment and in regenerative medicine. To reach this goal, concerted interdisciplinary approaches were pursued involving experimentalists competent in different techniques and theoreticians with expertise in analysing multimodal experimental datasets and integrating them into multi-scale models. InCeM achieved this by bringing together these experts and training a new generation of researchers. InCeM developed and used novel devices for multimodal and multidimensional recording techniques of subcellular processes, extracted quantitative data from these recordings and measurements, and integrated large datasets into mechanistic mathematical models. These models were validated experimentally and can be used for tuning cell migration in vitro and in vivo to benefit tumour patients and the millions of patients suffering from chronic wounds.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multiple components coordinated by structural, chemical and physical signals in terms of time and space. To accomplish breakthroughs in this field, researchers are needed who (i) master cutting-edge experimental techniques for monitoring the different cellular processes at high resolution and (ii) have competencies in theoretical science for integrating the resulting data sets into mechanistic mathematical models for predicting motile cell behaviour.The Research Training Network on Integrated Component Cycling in Epithelial Cell Motility (InCeM) aims to endow up-and-coming researchers with exactly these competencies. They will be able to develop and apply innovative devices for microscopic recording, image processing techniques, data analysis tools and modelling procedures for mechanistic understanding of cell migration. InCeM will focus on epithelial cells, since inducing motility in this cell type is clinically relevant for wound healing and cancer invasion. The ultimate goal is to control and manipulate cell migration for clinical applications. A dedicated multidisciplinary team of 11 beneficiaries from universities (4), research institutions (4) and industry (3), based in 5 European countries and Israel, together with 17 associated partners from the public and private sector, will train 15 Early Stage Researchers (ESRs) to use the relevant technologies and sciences and will offer business training to prepare them for successful careers in both academic and non-academic environments.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз