H2020Индивидуална стипендия2015–2016

FLUNOVELTY · Development of novel fluorinated reagents for preparation of drugs.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-11-01 → 2016-10-31
Финансиране от ЕС: 92 538 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Нови флуорирани реагенти се разработват за създаване на лекарства и селскостопански препарати, като например дифлуорилметилпиразоли. Тези методи позволяват по-евтино производство на пестициди, което може да доведе до намаляване на цените на храните.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development of novel fluorinated reagents for preparation of drugs.

The main objectives of Flunovelty project, performed at ESPCI (Paris, France) by Pavel Mykhailiuk with Prof. Janine Cossy, were to (a) develop the novel small fluorinated reagents; (b) to elaborate their novel reactions; and to (c) use this knowledge to discover novel synthetic approaches towards some known drugs. In fact, during this project we discovered the novel chemical reagent: difluoromethyldiazomethane (CF2HCHN2), and elaborated its chemistry. In particular, we used this reagent to synthesize diversely substituted difluoromethylpyrazoles: the core structures of known argochemicals: Bixafen (Bayer), Sedaxane (Syngenta), Fluxapyroxad (BASF) and Isopyrazam (Syngenta). In summaty, we have discovered a novel and cheaper approach to known agrochemicals. We believe that these methods will be finally implemented by agrochemical companies that will result in lowering the price of the corresponding pesticides, and eventually the food.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Around 20% of all modern drugs are fluorinated organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical reagents and reactions towards “drug-like” compounds. In this project, we will address this issue by discovering novel small fluorinating reagents - fluorinated diazoalkanes, - elaborate their practical reactions, and use this knowledge to develop alternative synthetic approaches to some known drugs (AS-136A, Celecoxib).

Оригинален текст от CORDIS (на английски).

Участници

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS · ParisКоординаторФранция