H2020Индивидуална стипендия2016–2018

RESCUE THE HEART · Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-04-01 → 2018-03-31
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нервните механизми и рефлексите, които предпазват сърцето при спиране на кръвопотока, се анализират чрез стимулиране на отдалечени тъкани. Разбирането им помага за намаляване на уврежданията след инфаркт и забавяне на развитието на хронична сърдечна недостатъчност.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts

Ischaemic heart disease is one of the most common causes of morbidity and mortality in the developed world. Occlusion of a major coronary artery is followed by myocardial metabolic and functional changes that develop rapidly after cessation of the blood flow. Manifestations of myocardial injury include arrhythmias, contractile and endothelial dysfunction and lethal reperfusion injury of cardiomyocytes. Remote ischaemic preconditioning (RPc) cardioprotection is the phenomenon whereby cycles of ischaemia/reperfusion (I/R) applied to an organ or tissue remote from the heart protect cardiomyocytes against I/R injury. In experimental studies, RPc results in 50% reduction in infarct size. However, clinical trials on RPc in patients gave neutral results due to poor understanding of the mechanisms underlying this powerful phenomenon of inter-organ protection. We have previously shown that RPc involves recruitment of autonomic reflexes and is critically dependent on parasympathetic vagal innervation of the heart and activity of a distinct group of vagal preganglionic neurones. This project was designed to advance the understanding of the mechanisms that protect the heart against I/R injury and slow down the development of chronic heart failure. Its central research questions included: 1) The significance of autonomic (sympathetic and parasympathetic) outflow to the heart in determining the extent of I/R injury. 2) The role of neural mechanisms in the cardioprotective effect of RPc. 3) How these neural mechanisms can be applied to reduce the extent of myocardial injury after infarction and to delay the development of chronic heart failure.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE LONDON · LondonКоординаторОбединеното кралство