Pharmcophore-DOS · Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-06-01 → 2017-05-31
- Финансиране от ЕС
- 195 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Разработва се нов метод за откриване на вещества, които блокират взаимодействието между протеините RAD51 и BRCA2. Този подход помага за по-бързото идентифициране на подходящи съединения за създаване на нови терапии при трудни за лечението мишени.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2
Given the difficulty in drug discovery, in particular when protein-protein interactions are targeted, we proposed a innovative strategy to identify hits and lead compounds for non- or difficult-drugged targets. Such an approach could accelerate the drug discovery and enhance the possibility of success in launching novel therapy to suffering patients. In our research, this novel strategy was developed and validated, and is hopeful to be expanded to more targets.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy. The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators. The researcher will acquire novel technologies and develop new skills in both scientific and management aspects, which are important in his professional maturity and career plans; while the host can also be benefitted from his experience in medicinal chemistry. This action will promote the mobility inside the European Research Area and spark lasting cooperation among different European countries.
Оригинален текст от CORDIS (на английски).
Участници
- THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз