H2020Индивидуална стипендия2015–2017

CLOPRESS · Renal Chloride Chanels and Blood Pressure Regulation

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Хлорните канали в бъбреците регулират нивата на кръвното налягане в организма. Разбирането на този механизъм помага за по-доброто управление на артериалното налягане.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Renal Chloride Chanels and Blood Pressure Regulation

When Yusuke Kumai, the post doc who applied for the Pierre et Marie Curie fellowship arrived in my lab he could not start immediately because due to the french legislation, he had first to complete a training to be allowed to work with animals. Indeed, the american certification he had was not valid in our country. Thus, he was waiting to a training course in english and was during this waiting period training to be able to perform the basic techniques that we were using in my laboratory. Then he was supposed to train after his summer vacations. Unfortunately, Yusuke Kumai did die accidentally during his hollidays and the project never really started. For this reason I can not really answer to the different questions of the commision about the project.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Hypertension, or elevated arterial blood pressure, is a significant global health concern. A major cause of hypertension is the abnormality in salt (NaCl) handling in distal nephron segments within kidney. Although there has been long a debate with regard to the relative importance of Na+ vs. Cl- in inducing salt-sensitive hypertension, previous research demonstrated that excess intake of Cl- could lead to severe salt-sensitive hypertension. Thus, better understanding on molecular mechanisms of renal Cl- handling would provide useful insights in treatment of hypertension. Previous studies largely focused on the identification and regulation of apically expressed Cl- transporters, including Na+-Cl- cotransporter, Na+-K+-2Cl- cotransporter (NKCC1/NKCC2) and pendrin, but mechanisms and regulation of Cl- transporters on basolateral membranes (i.e. an exit of Cl- into the interstitial space) remains poorly described. Thus, the current proposal will investigate the physiological role of basolateral Cl- channel distributed in distal nephron, specifically ClC-kb. Using a transgenic ClC-kb knockout line of mice, I propose to investigate the physiological role of this channel within isolated tubule and at the whole animal level. In addition, ClC-kb channel is known to interact with a functional β-subunit, barttin, and this interaction could affect Cl- conductance. I propose to investigate the molecular mechanisms by which barttin can affect ClC-kb-mediated chloride transport. The proposed studies will shed new insights into the molecular mechanisms of Cl- reabsorption in distal nephron, and could provide a basis for novel approach in treatment of hypertension.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция