H2020Индивидуална стипендия2015–2017

NIBSAD · Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-11-01 → 2017-10-31
Финансиране от ЕС: 180 277 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Неинвазивната стимулация на мозъка чрез магнитни импулси или слаб ток се тества, за да се открият най-ефективните параметри за подобряване на паметта и мисленето. Това ще помогне за повишаване на ефективността на програмите за когнитивна рехабилитация при здрави възрастни и хора с Алцхаймер.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease

The ageing of the European population is increasing the prevalence of age-related diseases such as Alzheimer’s disease (AD). AD is considered a public health priority due to the high socio-economic costs that it involves and the limited efficacy of the current pharmacological treatments. Non-invasive brain stimulation techniques (NIBS) such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) represent promising tools for improve cognitive functioning and prevent and/or delay the cognitive deficits related to AD. However, the optimal NIBS parameters (for example, type of tDCS current, intensity, frequency of the applied TMS pulses, targeted brain area, state of the participants during the application of NIBS protocols -for instance, resting state vs. performing a cognitive task) that would lead to maximize the cognitive improvement as well as the neurophysiological mechanisms underlying the cognitive changes are poorly understood. The main objective of this project was contributing to identify the optimal TMS and tDCS parameters that are able to improve cognitive functioning and investigating the underlying neural modulations in healthy elderly and AD patients. This objective is of vital importance because it will allow improving the efficacy of the current cognitive rehabilitation programmes.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Ageing of the European population is increasing prevalence of age-related diseases such as Alzheimer’s disease (AD). AD is considered a public health priority due to socio-economic costs and limited efficacy of current pharmacological treatments. Co-registration of electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) is a novelty, non-expensive and non-invasive approach to obtain surrogate markers of cognitive decline. Moreover, repetitive TMS (rTMS) is considered a promising tool to induce neuroplasticity and improve cognitive functions. The main objective of this research is providing markers of brain activity, reactivity, connectivity and plasticity related with healthy and pathological ageing (i.e., early AD). Thus, samples of healthy young, healthy elderly and AD patients will perform a behavioural task (to study visuospatial attention and cognitive control processes) while carrying out EEG recording and online EEG/TMS co-registration. Correlates of brain activity (event-related brain potentials), reactivity (amplitude of TMS evoked potential -TEP) and connectivity (TEP topography, coherence, synchronization, and graph theoretical analysis of complex networks) will be obtained before and after of delivering offline rTMS. It will allow studying differences in cortical responses induced by rTMS on each group of participants, which will provide correlates and biomarkers of brain plasticity related with age and AD. These biomarkers will allow the identification of individuals at early stages of AD and evaluating efficacy of novel TMS treatments. Importantly, identification of rTMS parameters responsible to induce neural plasticity and improve cognitive functions will contribute to develop rehabilitation protocols for AD patients.

Оригинален текст от CORDIS (на английски).

Участници

PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI · BRESCIAКоординаторИталия