Metabolic cost of walking · Stepping forward in understanding the Metabolic Cost of Human Walking
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-04-01 → 2017-03-31
- Финансиране от ЕС
- 177 599 €
- Участници
- 1
- Схема
- MSCA-IF-EF-RI
Линиите свързват координатора с партньорите.
Накратко на български
Енергийните разходи при ходене се анализират чрез измерване на кислорода в мускулните влакна и биофизично моделиране на тялото. Разбирането на тези механизми помага за подобряване на мобилността и качеството на живот при възрастни и хора с увреждания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Stepping forward in understanding the Metabolic Cost of Human Walking
Walking accounts for up to 30% of an adult's daily energy cost. The cost of walking is greatly increased in elderly and impaired people (up to 100% compared to young adults), which negatively impacts mobility, independence and quality of life. It is currently impossible to explain the metabolic cost of walking. Unravelling the mechanisms underlying this metabolic cost is of both fundamental and applied interest. For example, it is essential to improve locomotion and thereby quality of life in elderly. To understand the mechanisms underlying the metabolic cost of walking, we need to know how the energetic cost at the level of an organism as a whole –measured through O2 uptake– is related to that at the level of the motors: the muscles. The energetics of muscles contracting under circumstances resembling locomotion are unknown. We propose to study its key determinants by using an integrative approach, from physiology at the muscle-fibre level to biophysical modelling at the whole-body level. A central part in our approach is to perform experiments using a unique set-up for directly measuring of O2 consumption of muscle-fibres contracting under circumstances akin to walking; this has never been done before. The experimental results will be used to improve and validate the mechanical and energetic behaviour of our muscle-tendon complex models. Detailed models of the human musculoskeletal system will be used in an attempt to predict in vivo muscle contractile states and from that O2 uptake during isolated human knee extension/flexion movements against different loads, and during human walking. Our integrative approach to study energetics at levels ranging from muscle-fibres to the whole body is expected to have a broad impact on various fields of theoretical and applied life sciences.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking. In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking. This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective.
Оригинален текст от CORDIS (на английски).
Участници
- STICHTING VU · AmsterdamКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз