H2020Индивидуална стипендия2015–2017

STOP-Beta · Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-04-30
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Електрическата стимулация на мозъка при болест на Паркинсон се анализира, за да се разбере дали адаптивният метод подобрява способността на пациентите да забавят реакциите си при трудни решения. Това помага за намаляване на страничните ефекти от стандартното лечение.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control

Parkinson’s disease is a common neurodegenerative disorder, which strongly affects patients’ ability to control movements. Electrical stimulation of a deep-seated brain region (the subthalamic nucleus) has been shown to significantly improve motor function and quality of life in Parkinson’s disease. This treatment, which is referred to as deep brain stimulation (DBS), is particularly helpful in patients, who developed side-effects to their Parkinson drug treatment. However, DBS also has unwanted effects, such as impairing patients’ ability to delay or slow down their responses when faced with difficult or conflicting choices. Recent technological advances in DBS render it possible to adjust stimulation to ongoing brain activity so that stimulation is only turned on when brain activity is thought to be abnormal. This method, referred to as closed loop DBS, has been shown to be just as effective as conventional DBS that is turned on continuously, even though closed loop DBS only delivers electrical stimulation ~ 50% of the time. Given that stimulation is applied less frequently, it is conceivable that closed loop DBS might alleviate some of the side effects observed during conventional DBS. Indeed, it has recently been demonstrated that closed loop DBS has less negative effects on speech compared to conventional DBS. It remains, however, unknown whether closed loop DBS also preserves patients’ ability to slow down responses during difficult decisions. In this project, we aimed to assess (i) what function is normally (i.e. in the absence of DBS) carried out by the subthalamic nucleus (ii) whether closed loop DBS changes how patients make responses during decision-making, and (iii) what ‘mechanisms’ are affected by DBS that interfere with physiological control of responses during decision-making.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.

Оригинален текст от CORDIS (на английски).

Участници

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OxfordКоординаторОбединеното кралство