H2020Индивидуална стипендия2015–2017

AutismRigidPercept · Investigation and modification of atypical dynamic brain activity underlying perceptual inflexibility of autism spectrum disorders

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-05-01 → 2017-07-31
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Невроанатомията и мозъчната активност при аутизъм се анализират, за да се разбере защо някои хора трудно променят поведението си при нови ситуации. Познаването на тези механизми помага при адаптирането на тези хора към обществото и създаването на бъдещи терапии.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Investigation and modification of atypical dynamic brain activity underlying perceptual inflexibility of autism spectrum disorders

What is the problem/issue being addressed? In this project, we investigated neuroanatomical characteristics and functional mechanisms underlying inflexible behavioural and cognitive tendency of autism spectrum disorder (ASD). Why is it important for society? Despite its high prevalence, the biology of such cognitive inflexibility in autism has not been sufficiently investigated, which partly results in the difficulty of autistic individuals in adapting themselves to a rapidly changing modern society. Therefore, it should be highly significant to understand neurobiological mechanisms behind this ASD symptom. What are the overall objectives? We aimed at deepening biological understanding of this somewhat overlooked core symptom of autism, and building a foundation for future treatments for it.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Perceptual and cognitive inflexibility is considered to underlie the repetitive and restricted behaviours of autism spectrum disorder (ASD). However, despite its severe effects on daily life of autistic individuals, the biological basis of these ASD core symptoms remain little known. In this project, I will investigate the neural mechanisms behind this fundamental mental inflexibility of ASD by examining neural activity during bistable perception, which is thought to be suitable for evaluation of such mental and perceptual rigidity. To detect neural responses from the brains of autistic individuals during such fluctuating perceptual experience, I will empirically calculate the energy landscape of brain activity from non-invasive measurements of brain activity and numerically simulate activity transition on the energy surface. Given the explanatory power of this method demonstrated by my preliminary data, this project is expected to provide the first empirical evidence for autistic impairments in dynamic brain activity that underlies the mental inflexibility of ASD. Furthermore, successful completion of this main project will provide insight for a novel non-invasive intervention protocol to mitigate such autistic cognitive rigidity, which will be subsequently tested within this research project. I believe that this project has the potential to provide a novel integrative perspective to understand autistic cognitive inflexibility and presents a promising approach to modify these relatively overlooked symptoms.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE LONDON · LondonКоординаторОбединеното кралство