MagProtoCell · Magnetic micromachines based on protocell design and engineering
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-05-01 → 2017-04-30
- Финансиране от ЕС
- 183 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Магнитни протоклетки (изкуствени структури, подобни на клетки) се разработват за управление чрез външно магнитно поле, за да пренасят например ензими до конкретни места. Това помага за подобряване на клиничната диагностика, целенасоченото доставяне на лекарства и почистването на замърсители от околната среда.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Magnetic micromachines based on protocell design and engineering
The main objective of MagProtoCell was the design and construction of magnetic field-sensitive protocells (i.e., artificial cell-like entities) whose motility could be remotely controlled by an external magnetic field. In doing so, a new class of magnetic micromachines will be developed capable of delivering biomimetic functions embedded within the protocellular compartments such as enzyme-mediated catalysis, gene expression, etc. to localized sites under precise temporal and spatial control. From an applied point of view, enabling controlled motility of protocells in fluidic environments is crucial for the development of emerging applications of potential impact on energy production, public health and environmental issues such as clean-up of trace pollutants, clinical diagnosis, targeted drug delivery, control of microscale bioreactions or lab-on-a-chip devices. Some of these applications can be considered as Key Enabling Technologies (KETs), which will foster the Industrial Leadership pillar of Horizon 2020 (H2020) and the development of a European bioeconomy.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Protocells are artificial cellular systems exhibiting lifelike properties, which are proposed as a stepping-stone for understanding the origin of life on Earth. Features such as encapsulation, replication, metabolism and selective exchange of chemicals with the environment will enable their use as micromachines in a number of emerging applications (e.g., environment clean-up, clinical diagnosis, drug delivery, remote sensing, bioreactor technology). However, progress in such applications will be enhanced by the synthetic construction of protocells capable of directed movement in fluidic environments in response to external stimuli. To date, motility has been achieved only in a few cases, which involve a response to changes in chemical concentrations (chemotaxis) in the surrounding medium. However, controlling the chemical composition of the local environment is challenging, and thus alternative ways to stimulate motility are needed. In this regard, external magnetic fields (MFs) will enable high levels of control of protocell motility and spatial disposition to be achieved by employing noncontact forces. This is the aim of this proposal: to design and construct synthetic protocells able to sense and respond to external MFs. A key outcome of the work will be the development of a new class of magnetic micromachines based on protocell design and engineering. Such machines will couple MF-directed motility with the temporal and spatial delivery of advanced biomimetic functions. The key factor of the proposed methodology is the inclusion of colloidal magnetic particles at strategic locations in the protocell composition or in the external medium. Thereby, the expertise of the applicant (Dr. Rodríguez Arco) in the field of MF-responsive materials will be applied to the multidisciplinary and cutting-edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof. Mann FRS) has made great progress in the last few years.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз