H2020Индивидуална стипендия2015–2017

TANYFEEDNEURONS · Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-10-01 → 2017-09-30
Финансиране от ЕС: 185 076 €
Участници: 1
Схема: MSCA-IF-EF-RI

Линиите свързват координатора с партньорите.

Накратко на български

Таницитите са специализирани клетки в мозъка, които пренасят сигнали като глюкоза и лептин към невроните, контролиращи глада. Разбирането на тази комуникация помага за търсенето на нови методи за лечение на затлъстяване и диабет тип 2.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the circulating nutrient glucose, release the neuroactive factor adenosine triphosphate and the energy substrate lactate, both of which can potentially modulate neuronal activity. Tanycytes also permit the access to the brain of the blood-borne peptide leptin produced by fat to inhibit hunger. Understanding how this glia might interact with neurons that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders such as obesity, leptin resistance and type 2 diabetes. Therefore, the overall objective of the project was to determine how tanycytes could influence electrical activity of ARH neurons. More specifically, the project was based on answering the following questions: i) Does adenosine triphosphate released by tanycytes modulate activity of neurons that control food intake? ii) Do tanycytes interact with these neurons through the release of lactate? iii) How do tanycytes convey leptin to them? Towards this end, I used electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. The TANYFEEDNEURONS project provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and a leading cause of morbidity and mortality in Europe.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция