H2020Индивидуална стипендия2015–2017

EffectorTargets · Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-09-09 → 2017-09-08
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-RI

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Накратко на български

Белковите секрети на гъбичката Blumeria се тестват в дрожди и водорасли, за да се разбере как те променят работата на клетката на растението. Това помага за откриването на мерки за защита на реколтата от пшеница и ечемик.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

To understand the ways fungi infect their host, makes it possible to find protective measures. The fungus blumeria is a thread to global food security since it can destroy harvest of cereal crops like wheat and barley, which are staple foods for many people. This fungus uses a very large set of secreted proteins to alter the host cellular programs to its own benefit. We want to find out how the proteins operate by expressing them one-for-one in alternative hosts, yeast and the alga Chlamy.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This “arms race” between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as “effectors”. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins. Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.

Оригинален текст от CORDIS (на английски).

Участници

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonКоординаторОбединеното кралство