H2020Индивидуална стипендия2015–2017

RESCBONE · The influence of mechanical loading on the decline in bone mass with ageing

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-04-01 → 2017-03-31
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Механичното натоварване на костите при мишки се анализира, за да се разбере защо с възрастта се активират по-малко костни клетки (остеобласти). Това помага да се разбере как се развива остеопорозата и защо рискът от фрактури е по-висок при жените.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

The influence of mechanical loading on the decline in bone mass with ageing

Project Context and Objectives: Osteoporosis is an age and sex-related condition characterised by reduced bone mass, impaired micro-architecture and increased risk of low-trauma fractures. Osteoporosis-related fractures are a major health concern (occurring in 45 percent of Caucasian females and 13 percent of males) and impose a huge economic burden on health care systems. Bone mass and architecture in young people are normally adjusted to be able to withstand loading without fracture through a process of adaptation to functional loading. Osteoporosis represents a failure of this regulation particularly evident in women. We have shown in mice that their anabolic response to short periods of increased load-bearing is also impaired in an age and sex-related manner. Counter-intuitively, this response can be “rescued” in old female mice if short periods of loading are imposed against a background of disuse rather than normal activity. This “rescue” has not yet been demonstrated in males. We hypothesise from our other studies that the “lesion” in old mice, that appears to be “rescued” by concurrent disuse, involves reduced recruitment of osteoblasts (Ob). The primary objective of RESCBONE was to establish whether the age and sex-related decline in bones’ adaptive response to loading in mice can be located to a deficiency in the recruitment of the osteoblasts necessary to form new bone and, if so, whether it is this deficiency that can be rescued by appropriate manipulation of bone’s total loading experience.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Osteoporosis is an age and gender-related condition characterised by reduced bone mass, impaired micro-architecture and increased risk of low-trauma fractures. Osteoporosis-related fractures are a major health concern and impose a huge economic burden on European health care systems. In the young, bone adapts its mass and architecture in response to strains engendered by mechanical loading. However, this response in blunted in the aged. We have shown that the anabolic response to load is similarly impaired in an age and gender-related manner in mice. Counter-intuitively, this response can be “rescued” in aged female mice if short periods of loading are imposed against a background of disuse rather than activity. We hypothesise that this “rescue” involves increased recruitment of bone forming osteoblasts. The primary objective of this proposal is, to establish whether the age and gender-related decline in bone’s adaptive response to mechanical loading in mice can be attributed to insufficient recruitment of osteoblasts necessary to form new bone and, if so, whether this deficiency can be “rescued” by appropriate manipulation of bones’ loading environment. To achieve the objectives in this proposal, we will investigate bones from aged male and female mice, which have been subjected to mechanical loading with or without prior disuse. These will be compared with similarly treated bones of young mice. Our studies should further elucidate the mechanisms underlying the age-related decline in bones’ adaptive response to mechanical loading. We hope that these studies could identify novel therapeutic targets to augment bones’ natural anabolic response to physical activity/loading. This could be of particular relevance in maintaining bone mass in situations of aging, paralysis or even space flight. The proposal will strengthen the CV of the applicant and further collaboration between European laboratories.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство