RejuvenateBone · Enhancing the regeneration of bone defects in elderly: Rejuvenation of bone microenvironment
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-04-10 → 2018-06-10
- Финансиране от ЕС
- 178 157 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Възстановяването на костни дефекти при възрастни хора се изследва чрез използването на компоненти от „млади“ клетки и нови заместители на тъканите. Това е важно, защото с възрастта способността на тялото да зараства кости намалява, което затруднява стандартното лечение.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Enhancing the regeneration of bone defects in elderly: Rejuvenation of bone microenvironment
Bone defects resulting from trauma, tumor resection and bone diseases represent one of the most pressing health problems in the aging European population. Annually, over 2 million surgical procedures are required to repair bone defects in traumatology, orthopaedics, neurosurgery and dentistry. Current treatments include the transplantation of the patient’s own bone tissue from another site in the body, donated bone tissue from bone banks or various bone substitute materials that support new bone formation. However, all these options are associated with significant drawbacks, limiting the success of treatments. More importantly, they depend on appropriate function of bone cells to complete the process of bone healing. During aging, the regenerative capacity of cells in our body decreases due to a number of interacting cell-intrinsic and cell-extrinsic (microenvironmental) mechanisms. This means the success of bone therapies in elderly patients is in most cases limited. The treatments often require prolonged hospital stays and in many cases repeated surgeries, posing a high burden on the patients as well as extensive healthcare costs. Currently, there is only a limited number of treatments promoting the activity of bone forming cells. The overall aim of our project was therefore to investigate a new multidisciplinary approach to enhance new bone formation, based on recent advances in cellular reprogramming and tissue engineering. Our first objective was to prepare and study the components synthesized by young bone cells (obtained by cellular reprogramming) on aged bone cells from trauma patients. Our second objective was to develop bone tissue substitutes containing the components synthesized by young cells for transplantation. Our third objective was to test the developed bone tissue substitutes in pre-clinical models to evaluate their safety and bone healing potential.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Bone defects resulting from trauma, tumor resection and bone diseases represent one of the most pressing health problems in the aging European population. Current treatments of bone defects depend on a functional population of bone-forming (osteogenic cells) to mediate the process of bone regeneration. However during aging, the bone formation capacity decreases as a result of multiple interacting cell-intrinsic and cell-extrinsic mechanisms and the success of treatments in aged patients is in most cases limited. The aim of our project is to develop a new multidisciplinary approach to enhance the regeneration of bone defects in elderly, based on recent advances in cellular reprogramming and tissue engineering. We propose to investigate the extrinsic microenvironment components synthesized by young, embryonic-like osteogenic cells derived from human induced pluripotent stem cells, and test their potential to enhance the function of endogenous bone and vascular cells. We will focus our studies on the patients unable to benefit from the current therapies, due to advanced age and/or systemic conditions limiting their bone formation capacity. We will develop allogeneic, off-the-shelf bone tissue substitutes with the capacity to enhance the function of endogenous cell populations, and evaluate their safety and bone healing potential in preclinical models of bone repair. We hypothesize that ostegenic cells derived from reprogrammed adult/aged somatic cells can synthesize a “rejuvenated”, embryonic-like bone microenvironment with high regenerative capacity and enhance the bone healing processes mediated by aged endogenous cell populations. Our studies will provide new understanding of extrinsic mechanisms governing bone cell biology during aging and open new therapeutic possibilities for the aged patients currently lacking successful outcomes. The developed bone substitutes will also provide a valuable new model for basic biology studies and translational research.
Оригинален текст от CORDIS (на английски).
Участници
- LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG · WienКоординаторАвстрия
Връзки
Данни: CORDIS, © Европейски съюз