H2020Индивидуална стипендия2016–2017

EvoNovo · Genetic architecture of an evolutionary novelty: the development of the male-specific turban-shaped eyes of Cloeon dipterum

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-01-01 → 2017-12-31
Финансиране от ЕС: 158 122 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Генетичният механизъм за развитие на допълнителните турбановидни очи при мъжките екземпляри от вида Cloeon dipterum е в центъра на анализа. Това помага да се разбере как се появяват нови органи и структури в процеса на еволюцията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Genetic architecture of an evolutionary novelty: the development of the male-specific turban-shaped eyes of Cloeon dipterum

Morphological novelties are associated with innovative functions that have been conductive to major revolutions in the history of life: the development of limbs from fins to colonize the land, the invention of wings in insects that allowed the occupation of the air or the emergence of the placenta in mammals are amongst them. Nevertheless, it is still an open debate what genetic changes underlie these novelties, and whether these are generated through accumulation of progressive small changes or rather by major leaps. Despite their importance in the history of life, how morphological novelty arises and evolves is a long-standing question in Evolutionary Biology. One of the most striking examples of a sexually dimorphic novel structure is the extra pair of eyes present in the males of the mayfly species Cloeon dipterum. The males of this species develop, in addition to the compound eyes (shared by males and females), an extra pair of extremely large dorsal, turban-shaped eyes. EvoNovo wanted to take advantage of this novel visual system to make ground-breaking advances in the way we understand the genetic forces that control the origin of new organs and structures during evolution. To investigate the appearance of the turbanate eye in C. dipterum, we combined a number of experimental approaches, including non-invasive imaging, gene expression analyses, genomics, transcriptomics, and epigenomics to knit the gene regulatory network responsible for the development of the turbanate eye. EvoNovo described the formation of this new organ in males and the regulatory networks that have evolved to originate this structure in the males of this species. In addition, the establishment of C. dipterum as a model serves to other researchers as a foundation for further investigations in an organism placed in a key position in the phylogeny of insects.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Evolutionary innovations are biological revolutions: new organs are critically associated with the emergence of new species and their exploitation of new niches. Despite their importance in the history of life, how morphological novelty arises and evolves is a long-standing question in Evolutionary Biology. In this proposal, I will address the genetic basis of the emergence of one of the most striking examples of a sexually dimorphic novel structure. Males of the mayfly species Cloeon dipterum develop, in addition to the compound eyes (shared by males and females), an extra pair of extremely large dorsal, turban-shaped eyes. To unveil the genetic forces that control the specification and development of this new visual system, I will combine a number of experimental approaches, including non-invasive imaging using X-Ray microtomography, gene expression analyses, genomics, transcriptomics, epigenomics and genome editing to knit a gene regulatory network. This network will be mapped in time and space onto the developing structures and it will help finding which genetic changes trigger the development of the turbanate eye and how these changes operate. This research will represent one of the most detailed studies to understand what are the genetic causes underlying morphological novelties. In addition, establishing C. dipterum as a model will serve as a foundation for further investigations in an organism placed in a key position in the phylogeny of insects, creating a new scientific line for my future establishment as an independent researcher.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания