H2020Индивидуална стипендия2015–2017

YAKUT · Genomics, epigenomics and transcriptomics of Yakutian horses, a unique domestic breed adapted to life in the Arctic

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-09-15 → 2017-09-14
Финансиране от ЕС: 200 195 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Генетиката и епигенетиката на конете от Якутия, както и сравнителният им анализ с други породи, се изучават чрез биологични проби. Това помага за разбирането на адаптацията към арктическия климат и развитието на методи за екологично моделиране.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Genomics, epigenomics and transcriptomics of Yakutian horses, a unique domestic breed adapted to life in the Arctic

The YAKUT project had as main aim the analysis of fresh and ancient biological horse samples from Yakutia, Siberia. Unexpected problems did not allow the work to be conducted as planned meaning contingency measures had to be developed and implemented. The supervisor and the researcher together developed two modified projects and new Work Packages (nWP) as described below. The Work Packages had almost identical titles to those in the original application, with the difference being the samples used and, for example, Yakutian has been switched with Italian. This allowed full training to the researcher, in particular to the latest methodological advances in genomic sciences and spatial distribution modelling through the new Work Packages (nWP) described below. The first project (nWP1 and nWP2) has been developed in order to ensure adequate training in the molecular methods required to obtain genetic data from ancient and modern biological material (as expected from WP1 and WP2 of the DoA), and the associated data analysis (as expected from WP3). The second part of the modified project (nWP4 and nWP5) was designed in order to ensure adequate, additional training in a field, paleo-ecological modelling, that represents a novelty in association to ancient DNA analyses, even if it is commonly used in other fields of biological research. This corresponded to a novel set of skills and approaches for which the researcher developed increasing interest, with the specific long-term objective to develop research projects merging (ancient and modern) genome-scale data and ecological modelling. This second project thus broadened the range of skills for the researcher, opening her to spatial distribution modelling and climate niche projection and reinforcing her position as independent and mature professional. nWP1 Characterisation of the past genomic diversity of Italian horses nWP2 Characterizing the present genomic diversity within Italian horses nWP3 Reconstruction of the demographic history of ancient (Italian) horses and their relationships to present-day (Italian) breeds nWP4 Establishment and analysis of a spatially-explicit database of radiocarbon dates and relative frequencies associated to horse presence in Eurasian archaeological sites. nWP5 Reconstruction of the Palaeoecology of the horse in Eurasia.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Yakutia (Sakha Republic, Russian Federation) is the coldest country in the Northern hemisphere with winter record temperatures as low as -70ºC. Despite such extreme conditions, the Yakut people succeeded in developing an economy based on extensive horse and cattle breeding. In contrast to cattle, that are parked in stables at winter, horses do not receive much human care, living all the year in the open air and grazing on vegetation that is under deep snow cover for 7-8 months. Unsurprisingly, Yakutian horses developed amazing adaptations to life in the cold Arctic, including exceptional hair densities for domestic horses and spectacular capacities for regulating their metabolism. The origin of Yakutian horses is controversial. In the YAKUT project, we will use cutting-edge genomic tools including genomics, transcriptomics and epigenomics, together with state-of-the-art methods in ancient DNA research, to reconstruct the evolutionary history of Yakutian horses from its mysterious origins to its adaptation to life in the Arctic. Our extensive genomic dataset will provide essential information to foster efforts for developing sound management strategies to preserve this unique genetic heritage. Following seasonal gene expression levels and associated epigenetic modifications at the whole genome scale, we will reveal for the first time the mechanisms responsible for the exceptional metabolic adaptations found in Yakutian horses. Overall, the YAKUT project aims at understanding the process of natural selection underlying the adaptation of a domestic breed to life in an extreme environment.

Оригинален текст от CORDIS (на английски).

Участници

KOBENHAVNS UNIVERSITET · KOBENHAVNКоординаторДания