H2020Индивидуална стипендия2016–2018

DAMAGE · An avian model for understanding and preventing the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2016-02-01 → 2018-01-31
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Лошите условия по време на развитието на ембриона, като недостиг на ресурси, се изследват чрез модел с птици. Това помага да се разберат процесите, които влияят върху здравето, плодовитостта и стареенето в по-късната възраст.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

An avian model for understanding and preventing the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate

The conditions experienced by embryos during development can vary drastically between individuals. Such variations in the quality of developmental conditions are suspected to have both short and long-term consequences for individual health, which could affect longevity. This is for instance exemplified in humans by the well known impact of low or high birth weight on subsequent health at adulthood (e.g. risks of cardiovascular disease or type II diabetes). Understanding the physiological processes underlying these deleterious effects of poor developmental conditions that influence health state later in life is a major challenge in biology, which requires the development of appropriate animal models. The aim of this project was to develop an avian model for understanding the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate, since mammalian models do not allow the manipulation of embryonic development without any concurrent alteration of the mother’s state. In addition, the telomere biology of birds appears to be closer to the telomere biology of human than classical short-lived laboratory rodent models, which is especially important considering the putative role of this ageing pathway in explaining the long-lasting consequences of adverse developmental conditions. Overall, this Marie Curie Fellowship was a success in developing a new avian model to investigate the effects of poor developmental conditions on health state. Using this model, we were able to show that a variety of developmental stressors (i.e. accelerated or unstable development, but also low availability of resources) were associated with an accentuated shortening of telomeres, those protective structures of the genome that leads to cellular senescence when they reach a critically short length. These findings pave the way for testing potential preventive strategies in the future.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Poor developmental conditions have been shown to impact subsequent health, fertility and lifespan, both in human and animal models. However, the molecular, developmental and physiological mechanisms underlying these adverse effects on health later in life are still poorly understood. Since mammalian models do not allow manipulations of embryo development independently of maternal influence and nutritional state (i.e. without the mother potentially compensating for any manipulation), I will pioneer a new avian model using experimental controls of embryo growth and development through modulation of incubation temperature.The key goals of this postdoctoral project are:(i)To determine the extent to which developmental conditions (i.e. slow vs. fast embryo growth rate, developmental instability) induce deleterious effects on health, fertility and rate of ageing in later life.(ii)To identify the molecular and/or physiological mediators of such adverse effects, by targeting parameters related to the ageing process (mitochondrial functioning, oxidative stress, telomere erosion and cellular stress resistance) and investigating the ‘sparing of vital organs’ hypothesis.(iii)To test both pre- and post-natal antioxidant therapies as preventive strategies to limit the deleterious impact of poor growth conditions on subsequent health, fertility and rate of ageing.This project will use a novel approach to reveal completely new insights into the importance of developmental conditions for subsequent life-history trajectories and rates of ageing. It will also provide important insights for the poultry industry about the impact of developmental conditions and in ovo antioxidant supplementation on subsequent productivity and fertility.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF GLASGOW · GlasgowКоординаторОбединеното кралство