silvercatpharma · from gold to silver: streamlining metal-catalysed cross-coupling reactions
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2015-04-01 → 2017-03-31
- Финансиране от ЕС
- 158 122 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Метали от d-блока, като злато и сребро под формата на наноклъстери, се изследват за създаване на нови въглерод-въглеродни връзки. Това помага за по-евтин и екологичен синтез на биоактивни молекули, които могат да станат основа за бъдещи лекарства.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
from gold to silver: streamlining metal-catalysed cross-coupling reactions
SILVERCATPHARMA project aims at developing reactions for the formation of new carbon-carbon bonds catalyzed by d11-blocks metals and their application to pharmaceuticals in Novartis. The importance of the project lies on the fact that this reaction is pivotal for the construction of new molecules of different entities and great efforts should be put in order to find methodologies that allow the construction of new carbon-carbon bonds in a cheap and environment friendly manner. The development of reactions within the context of SILVERCATPHARMA represents the basis for the synthesis of bioactive molecules in Novartis; in the future these compounds can be potential candidates for the treatment of important diseases and so be the foundation for treatments that will reach thousands of people. In so doing we desire to show how basic research, such as the use of d-11 blocks metals in synthesis, plays a pivotal role for the disclosure of new molecules that can have a future effect on the population. SILVERCATPHARMA takes into account the important of the formation of new carbon-carbon bonds at an industrial level. For this reason it aims at the design of new metal-catalysed C-C reactions under mild conditions through the exploitation of small nanoclusters. The use of gold in this sense will help in to understand of the basic reactivity principles. Then, the attention will move onto gol-silver clusters as potential catalysts for the above mentioned reactions. Gold nanoclusters are a promising class of model catalysts. They will provide new opportunities for the comprehension of metal nanocatalysis and for the new design of highly selective catalysts for specific chemical processes. The possibility of a rational design of gold and silver clusters for the synthesis of fine chemicals represents a way to optimize the outcome of reactions.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Silvercatpharma project aims at developing C-C cross-coupling reactions catalysed by d11-blocks metals, particularly silver, for the synthesis of pharmaceuticals in Novartis. It strives to have an impact in terms of cost, environment and international visibility because of the use of silver as an alternative catalyst. The project offers me a great opportunity to obtain further training, such as clusters preparation, computational and flow chemistry, and to define my final career in academia or industry because of the possibility of working in these two different environments.
Оригинален текст от CORDIS (на английски).
Участници
- FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA · TARRAGONAКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз