NBSC · Neural basis of semantic control
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2016-02-01 → 2018-01-31
- Финансиране от ЕС
- 183 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
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Накратко на български
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Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Neural basis of semantic control
Every form of semantically-driven human behaviour is supported by ‘semantic control’, which refers to executive processes that regulate access to semantic knowledge. In verbal and nonverbal tasks, semantic access needs to be ‘regulated’ in a time and context specific fashion to allow appropriate behaviours. In general terms, semantic control is known to be supported by frontal-parietal-temporal brain areas. Nevertheless, the specific networks and the exact contribution of each area in the networks to semantic control remain to be determined yet. Addressing these challenging questions is crucial to understand how semantic control is implemented in the brain and, therefore, healthy and pathological functioning during everyday verbal and nonverbal semantic activities (e.g., speaking, object use). Besides advancing our general understanding, these questions are also important to guide clinical research and practice, since different parts of the network can be affected by brain damage. The overall goal of this project was to reveal the brain areas and the neural networks underpinning semantic control and to provide new evidence on their functional specialization. To do so, we adopted a multimethod approach that ultimately provided convergent evidence on these key issues. In fact, by carrying out functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) studies we have been able to localize the brain structures and the networks engaged in semantic control and to test whether a brain region revealed by fMRI would have had a necessary role for semantic control.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Every form of semantically-driven human behavior is supported by semantic ‘control’, which refers to executive processes that regulate access to semantic knowledge. To understand everyday verbal and nonverbal activities (e.g., speaking, object use), as well as impairments after brain damage, it is crucial to establish how semantic control is implemented in the brain. In general terms, semantic control is known to be supported by a network of frontal-parietal-temporal brain areas. However, the exact contribution of each area to semantic control and whether each is specific to semantic control or part of a general cognitive control function, remain to be determined. Besides advancing basic science these questions are clinically important as different parts of the network can be affected by brain damage. The goal of this project is to answer these questions by carrying out two fMRI investigations and one TMS study, on the very same participants. This novel combined multimethod approach ensures that this project will provide convergent evidence on these key issues. To find specializations related to different types of semantic control, we will first run an fMRI study with a semantic association task comparing two different conditions that differ only for the type of semantic control processes required. To explore the extent to which these functional specializations are dedicated to semantic control, we will run a second fMRI study with a non-semantic association task and we will compare control effects across semantic and non-semantic tasks. To test whether the brain areas revealed by fMRI have a necessary role for different types of semantic control, we will run a TMS study during a semantic association task. Thus, additional innovative aspects of this project reside in measuring neural priming disruption effects with fMRI and in using online single-pulse TMS, to allow more precise evaluation of the contribution of each area and its time-course in semantic control.
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY OF MANCHESTER · ManchesterКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз