H2020Индивидуална стипендия2015–2017

MSMART · Margination of Microcapsules in Small Arteries

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-09-03 → 2017-09-02
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Микрокапсулите, използвани за пренос на лекарства, се изследват при движението им от центъра на кръвния поток към стените на малките артерии. Това помага за подобряване на точността при доставянето на медикаменти и намаляване на страничните ефекти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Margination of Microcapsules in Small Arteries

Vascular-targeted drug delivery using micro/nano-particles as drug carriers have been exploited in recent years in therapeutic interventions of cancer, cardiovascular, pulmonary and inflammatory diseases and so on. This approach has numerous advantages over conventional delivery (e.g., lower drug dosage and thus reduced side effects, sustained release), however, a major challenge is to improve cell selectivity and wall-adhesion efficiency by functionalizing the drug carriers. Extensive research has focused on identifying disease-associated biomolecules on the endothelium, or suitable antibody/peptides targeting these molecules, however, much less attention has been paid to a crucial haemodynamic aspect: will the drug carriers be able to migrate from the midstream of the blood to the RBC-free layer close to the vessel wall, under complex interactions with blood cells? This is particularly important in small arteries, where many diseases (e.g., arteriolosclerosis) develop but surgical operations become difficult. The aim of the present project is therefore to conduct a systematic study of the effects of system parameters, such as the blood flow condition, the particle shape, size etc on the cross-stream migration and margination of microparticles in blood flows in small arteries. Specific research objectives are: 1, to develop experimental and computational platform to study the cross-stream migration and margination of microcapsules in blood flow in small arteries; 2, to investigate the effects of system parameters, such as the shape and size of the capsule, the flow inertia and shear rates, vessel geometry etc. on margination of microcapsules in blood flows; 3, to develop practical principles for engineering microcapsules with optimum margination in blood flow in small arteries. All three research objectives have been largely achieved during the fellowship period.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Intravascular delivery of microcapsules is emerging as a novel and effective approach in targeted therapeutic and diagnostic procedures in cancer and cardiovascular diseases. It encapsulates drugs or imaging-contrast agents and functionalizes the surface of the capsule to target specific diseased sites. However, a major challenge in its applications is to improve the adhesion efficiency of capsules to the endothelium (a monolayer of cells that lines the luminal surface of blood vessels) under complex blood flow conditions. While extensive research has focused on identifying disease-associated biomolecules on the endothelium, or suitable antibody/peptides targeting these molecules, much less attention has been given to the margination of the drug carriers from the blood stream to the vascular wall, especially in arteries where many diseases develop. Margination represents the crucial first step before adhesion. The aim of this project is therefore to investigate the cross-sectional migration of microcapsules in arterial blood flows and to develop scientific understanding of how the size, shape and deformability of capsules, as well as system parameters such as the blood haematocrit, blood flow inertia and pulsatility, and vessel geometry affect the margination of the microcapsules. The project will unit the state-of-the-art in-vitro, ex-vivo experimentation and numerical modeling resolving blood flow at a cellular level. A second aim of the project is to develop practical principles for designing microcapsules with optimum margination property in arteries. The project will pave the way for novel designs of injectable medicines or imaging-contrast agents with enhanced vascular targeting efficiency.

Оригинален текст от CORDIS (на английски).

Участници

QUEEN MARY UNIVERSITY OF LONDON · LONDONКоординаторОбединеното кралство