H2020Индивидуална стипендия2015–2017

MWMI · Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2015-12-01 → 2017-11-30
Финансиране от ЕС: 171 461 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Микроструктурата на бялото вещество в човешкия мозък се анализира чрез нов метод за ЯМР, за да се измерят параметри като дебечината на миелиновата обвивка. Това помага да се разбере как физическите промени в нервните пътища влияят върху работата на мозъка и усещането за болка.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework

The main goal of this Marie-Curie project was to improve our understanding of the human central nervous system (CNS) by extending our knowledge of the white-matter micro-scale composition, which is integral to brain function. Information flow in the brain is conveyed from the periphery via white matter pathways in the spinal cord to the cortex. However, it is currently not known to which degree the micro-scale composition of these pathways (e.g. myelin-sheath thickness or axonal diameter) determines the performance of functional networks associated with the cortex. The goal of this proposal was to develop a novel computational in-vivo MRI method, which we call Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will allow the assessment of 4 specific micro-scale metrics at high spatial resolution: myelin, water concentration, axonal density and the ratio between inner and outer fiber diameters (g-ratio) - a surrogate measure for the conductance speed in a fiber. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging (DTI), can detect microstructural changes but do not provide any information on the origin of these changes. In contrast, MWMI is capable of detecting microstructural changes and in addition provides insight into the underlying processes leading to these changes (e.g. whether pain leads to axonal reorganization or (de)myelination). To main objectives of this project can be summarized as follows: (i) To develop biophysical models that link the MR signal to the microscopic tissue composition. (ii) To achieve high spatial resolution and integration of different MRI techniques. (iv) To apply these MWMI methods to the pain circuit, which is a fundamental and well-described circuit of the human CNS. (v) To disseminate the MWMI method to the community by providing an imaging protocol and an open-source toolbox to the community.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 μm: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diameter (g-ratio) - a surrogate measure for its conductance speed. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging, can detect but not determine the origin of microstructural changes, whereas MWMI will both detect microstructural changes and identify their origin (e.g. whether learning leads to axonal reorganization or myelination). To facilitate MWMI, 3 major methodological innovations will be developed: (a) Advanced biophysical models: Unlike existing biophysical models (e.g. axonal diameter model), which are ill posed due to the restriction to one qMRI mechanism, MWMI will combine 4 different qMRI mechanisms (relaxometry, diffusion MRI, magnetization transfer, and proton density imaging) to better condition its models. (b) Spatial integration: Novel physically-informed artifact correction methods will allow spatial integration of high-quality maps from 4 different qMRI techniques with sub-voxel accuracy. (c) Mesoscopic resolution: Unlike standard biophysical models and qMRI, the unprecedented resolution of MWMI will allow estimating micro-scale metrics within the white matter that are unbiased by partial volume effects.The pain circuit, which is a fundamental and well-described sense, will be used to demonstrate the feasibility of MWMI. Longitudinal MWMI be performed to measure micro-scale correlated of nociceptive long-term habituation in the spinal cord, the first and crucial anatomical structure associated with pain.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF · HamburgКоординаторГермания